Traditional methods for age determination of wildlife include either slicing thin sections off or grinding a tooth, both which are laborious and invasive. Especially when it comes to ancient valuable museum samples rare extinct species, non-invasive preferable. In this study, X-ray micro-computed tomography (µ-CT) was verified as an alternative method three species within the order Carnivora su...

AIMS The risk of ischaemic heart disease (IHD) death in early type 1 diabetes onset was assessed using death certification data. METHODS The Yorkshire Register of type 1 Diabetes in Children and Young People was linked to clinically validated death certification data for those diagnosed under 15 years. Standardised mortality ratios (SMRs) were calculated using the England and Wales population...

Background: Logistic discriminant method was applied to differentiate malignant from benign in a group of patients with proved breast lesions on the basis of ultrasonic parameters. Materials and Methods: Our database include 273 patients' ultrasonographic pictures consisting of 14 quantitative variables. The measured variables were ultrasound propagation velocity, acoustic impedence and attenua...

the method has been developed and validated for the determination of hydroquinone in liposomal formulation. the samples were dissolved in methanol and evaluated in 293 nm. the validation parameters such as linearity, accuracy, precision, specificity, limit of detection (lod) and limit of quantitation (loq) were determined. the calibration curve was linear in 1-50 µg /ml range of hydroquinone an...

OBJECTIVES This study aimed to establish a stature-predicted equation using knee height, and perform a clinical validation on a Korean population. METHODS Using nationwide data obtained from 'Size Korea 2004', a stature-predicted equation was drawn and cross validation was performed using knee height in 5,063 subjects (2,532 males, 1,785 premenopausal females, and 746 postmenopausal females) ...

Previous studies have shown that both single nucleotide polymorphisms (SNPs) and questionnaires-based method can be used for twin zygosity determination, but few validation studies have been conducted using Chinese populations. In the current study, we recruited 192 same sex Chinese adult twin pairs to evaluate the validity of using genetic markers-based method and questionnaire-based method in...

In vivo studies are an important tool for the identification and validation of novel drug targets in medicine; however, the interpretation of submitted and published data is often compromised by inadequate study design. Different study protocols, including the number of control groups and group size calculations, differ in target identification and validation studies. Furthermore, animal studie...