According to the similarity of the amino acid sequences in their catalytic domains, eukaryotic protein kinases have been classified into the five main groups: 'AGC', 'CaMK', 'CMGC', 'PTK' and 'other'. The AGC group, represented by the cyclic nucleotide-dependent kinases (PKA and PKG), the calcium-phospholipid-dependent kinases (PKC) and the ribosomal S6 protein kinases, are poorly characterized...

We unexpectedly observed strong nuclear overexpression of bcl-2 protein in advanced stomach cancer. As far as we know, such expression has not yet been reported. To investigate the significance of nuclear expression of bcl-2 protein in gastric carcinoma, we immunohistochemically analyzed bcl-2 overexpression in a gastric carcinogenic sequence, including 19 tubular adenomas (TA), 20 early carcin...

Biologically-motivated Automatic Gain Control (AGC) scheme of processing along various image dimensions is presented. Images are represented in a multidimensional space that incorporates less investigated dimensions such as curvature, size, depth, convexity/concavity and more. Similarly to the effect of AGC on processing of intensity in vision, the proposed scheme for multidimensional image pro...

The prognostic value of histological types in gastric cancer is not well defined. This study aims to clarify the clinicopathologic features of various WHO histological types and their prognostic significance in advanced gastric cancer (AGC). We retrospectively reviewed 741 patients with gastric cancer in our hospital from 1997 to 2007. The AGC (741 cases) were divided into five histological typ...

Activation of members of the protein kinase AGC (cAMP dependent, cGMP dependent, and protein kinase C) family is regulated primarily by phosphorylation at two sites: a conserved threonine residue in the activation loop and a serine/threonine residue in a hydrophobic motif (HM) near the COOH terminus. Although phosphorylation of these kinases in the activation loop has been found to be mediated ...

To preserve the natural balance, stability, and reliability of an electric power system, its frequency is one most relevant variables to control; therefore, control schemes by stages are used. In particular, secondary regulation, also known as automatic generation (AGC), performed remotely from a system operator’s center in cases using efficient energy management systems (EMS). They use SCADA-A...

The Acasta Gneiss Complex (AGC) is a ∼2,400 km2 Hadean-Mesoarchean terrane that contains the oldest known zircon-bearing rocks on Earth. Despite its importance for early Earth geology, only small fraction (∼50 km2) of AGC has been mapped in detail. We use detrital zircon grains from late Pleistocene eskers transect to approximate lateral extent and relative proportions diverse-aged ancient rock...

Cases of atypical glandular cells (AGC) diagnosed on liquid-based preparations were culled from a 3-year period. When available, residual cellular material was analyzed for human papillomavirus (HPV) by polymerase chain reaction and correlated with cytologic and histologic (biopsy) outcome. Of 178,994 cytologic cases, 187 (0.1045%) contained AGC compared with 8,740 (4.8828%) atypical squamous c...

The aim of this study was to investigate the frequency, location and type of katG mutations in Mycobacterium tuberculosis strains isolated from patients in Belarus. Forty two isoniazid-resistant isolates were identified from sputum of 163 patients with active pulmonary tuberculosis. Drug susceptibility testing was determined by using CDC standard conventional proportional method and BACTEC syst...

Pole placement is a control method assigned to arbitrary closed loop poles by state or output feedback. In linear systems, poles have influence on stability, system response, and transient response of the system. The applications of pole placement technique in power system operation and control have been found a significant place over the years. This paper presents salient features of pole plac...