In this study, we used nitrogen-doped titanium dioxide (N-TiO2) NPs in conjugation with visible light, and show that both reactive oxygen species (ROS) and autophagy are induced by this novel NP-based photodynamic therapy (PDT) system. While well-dispersed N-TiO2 NPs (≤100 μg/ml) were inert, their photo-activation with visible light led to ROS-mediated autophagy in leukemia K562 cells and norma...

OBJECTIVE There is a wide application of titanium dioxide (TiO2) nanoparticles (NPs) in industry. These particles are used in various products, and they also has biological effects on cells and organs through direct contact. MATERIALS AND METHODS In this experimental research, the effect of TiO2 on chondrogenesis of forelimb buds of mice embryos was assessed in in vivo condition. Concentratio...

Several studies have been performed to understand the influence of titanium dioxide nanoparticles (TiO2-NPs) on cell function; however the effects of nanoparticle exposure on the plasma membrane have not been addressed so far. Since this interaction may alter cell metabolism and integrity, it is of importance to understand the modifications of the cell membrane, in particular of epithelial cell...

Plasmonic hot-electron generation has recently come into focus as a new scheme for solar energy conversion. So far, however, due to the relatively narrow bandwidth of the surface plasmon resonances and the insufficient resonant light absorption, most of plasmonic photocatalysts show narrow-band spectral responsivities and small solar energy conversion efficiencies. Here we experimentally demons...

objective(s): titanium dioxide (tio2) nanoparticles (nps) are widely used in commercial food additives and cosmetics worldwide. uptake of these nanoparticulate into humans by different routes and may exhibit potential side effects, lags behind the rapid development of nanotechnology. thus, the present study designed to evaluate the toxic effect of mixed rutile and anatase tio2 nps on serum bioc...

we consider of the antimicrobial activity on the ag nanoparticles(ag nps) aqueous solutions, which was prepared using a stabilizer, such as poly(n vinyl 2 pyrrolidone pvp , for staphylococcus aureus) s aureus and escherichia coli e coli by measuring the minimum inhibitory concentration mic . antimicrobial effect of ag nps for s aureus and e coli was investigated using disk diffusion method also...

background and aims: although metal and metal oxide nanoparticles are used in different medical applications, they may have considerable toxicity on various cells, such as myocytes. therefore, this study aimed to evaluate the toxicity of the naked and serum-treated silver nanoparticles (ag nps) and magnesium oxide nanoparticles (mgo nps) on the cardiomyocytes. materials and methods: cardiomyocy...

Using magnetron sputtering and heat treatment, Ag@TiO2 nanotubes are prepared. The effects of heat-treatment temperature and heating time on the evolution of Ag nanofilms on the surface of TiO2 nanotubes and microstructure of Ag nanofilms are investigated by X-ray diffraction, field emission scanning electron microscopy, and transmission electron microscopy. Ag atoms migrate mainly on the outmo...

Titanium dioxide nanoparticles (TiO2 NPs) have been used in various medical and industrial areas. However, the impacts of these nanoparticles on neuroinflammation in the brain are poorly understood. In this study, mice were exposed to 2.5, 5, or 10 mg/kg body weight TiO2 NPs for 90 consecutive days, and the TLRs/TNF-α/NF-κB signaling pathway associated with the hippocampal neuroinflammation was...

The innate immune response is the earliest cellular response to infectious agents and mediates the interactions between microbes and cells. Toll-like receptors (TLRs) play an important role in these interactions. We have already shown that TLRs are involved with the uptake of titanium dioxide nanoparticles (TiO2 NPs) and promote inflammatory responses. In this paper, we compared role of cellula...