Much attention has focused on the effects of leptin as a central satiety agent. There is now a significant amount of evidence that leptin is active in the periphery. This review focuses on the ability of leptin to modify insulin sensitivity, tissue metabolism, stress responses, and reproductive function. Leptin's effect on several of these systems is mediated via the hypothalamic-pituitary axis...

AD (Alzheimer's disease) is a neurodegenerative disease characterized by a gradual loss of neurons and the accumulation of neurotoxic Aβ (amyloid β-peptide) and hyperphosphorylated tau. The discovery of mutations in three genes, PSEN1 (presenilin 1), PSEN2 (presenilin 2) and APP (amyloid precursor protein), in patients with FAD (familial AD) has made an important contribution towards an underst...

In Autumn 2004, HSE will launch a quarterly on-line newsletter ‘Science and Research Outlook,’ providing information on the breadth of HSE’s science and engineering activities. Science and Research Outlook will replace the existing HSE quarterly science newsletters, Mainstream Research News and Offshore Research Focus. Users of the newsletter’s interactive website will be able to search and pri...