BACKGROUND Grey matter and other structural brain abnormalities are consistently reported in first-onset schizophrenia, but less is known about the extent of neuroanatomical changes in first-onset affective psychosis. AIMS To determine which brain abnormalities are specific to (a) schizophrenia and (b) affective psychosis. METHOD We obtained dual-echo (proton density/T2-weighted) magnetic r...

Schizophrenia is a progressive illness, with many psychotic episodes. Brain imaging studies have consistently demonstrated brain abnormalities in patients with schizophrenia. These changes are largely confined to decreases in gray matter volumes and enlargement of the lateral and third ventricles. To date schizophrenia has been considered to result from abnormalities in neurodevelopment, with b...

Multiple neurotransmitters have been implicated in schizophrenia. Dopamine is the neurotransmitter most often hypothesized to be associated with the pathophysiology of schizophrenia for two reasons. First, dopaminergic agonists can cause or exacerbate psychotic symptoms. Second, the correlation between antipsychotic efficacy and D2 dopamine-receptor blockade is excellent. For these reasons, a n...

We hypothesized that sensory memory associated with the temporal window of integration (TWI) would be impaired in patients schizophrenia, an issue had not been evaluated using omission mismatch negativity (MMN) complex speech sounds. aimed to assess functional changes auditory TWI schizophrenia by investigating effect stimuli on MMN. In total, 17 and 15 control individuals participated study. T...

Schizophrenia has been conceptualized by dysfunctional cognition and behavior related to abnormalities in neural circuitry. The functioning of the neural circuitry can be assessed using the auditory steady state response (ASSR). Moreover, in recent years, research on high (>60 Hz) gamma band oscillations has become of increasing interest. The current study used whole-head, 306-channel magnetoen...

INTRODUCTION: Although common hematological abnormalities (CHA) such as anemia, macrocytosis, and platelet dysfunction are often present in patients with schizophrenia, empirical data limited. Thus far, deviations have been mentioned either reports or a series of clinical cases.
 AIM: To study the incidence CHA schizophrenia.
 MATERIALS AND METHODS: This involved 791 schizophrenia [in...

BACKGROUND Presumed obligate carriers (POCs) are the first-degree relatives of people with schizophrenia who, although do not exhibit the disorder, are in direct lineage of it. Thus, this subpopulation of first-degree relatives could provide very important information with regard to the investigation of endophenotypes for schizophrenia that could clarify the often contradictory findings in schi...