The objective of this study was to quantify the magnitude of genotype-environment interaction (GxE) effects on age at first calving (AFC), scrotal circumference (SC), and yearling weight (YW) in Nellore cattle using reaction norms. For the study, 89,152 weight records of female and male Nellore animals obtained at yearling age were used. Genetic parameters were estimated with a single-trait ran...

N-Acetyl-S-farnesyl cysteine (AFC) is the minimal synthetic substrate for the enzyme Icmt, which methylates prenylated proteins. The desthio-AFC isostere 2 has been synthesized in racemic form. This analog was not an Icmt substrate, but instead a weak inhibitor with an IC50 of approximately 325 microM.

background: the predictive roles of follicle stimulating hormone (fsh), anti-mullerian hormone (amh) and antral follicle count (afc) as ovarian reserve markers in women with different age groups are not established well. objective: this study compares the value of fsh, amh and afc at the time of     in vitro fertilization (ivf) treatment in different age groups. materials and methods: in this c...

Active flow control (AFC) involves manipulating fluid over time to achieve a desired performance or efficiency. AFC, as sequential optimisation task, can benefit from utilising Reinforcement Learning (RL) for dynamic optimisation. In this work, we introduce Gym-preCICE, Python adapter fully compliant with Gymnasium API facilitate designing and developing RL environments single- multi-physics AF...

BACKGROUND The epithelial sodium channel (ENaC) is the driving force for pulmonary edema absorption in acute lung injury (ALI). Netrin-1 is a newly found anti-inflammatory factor that works by activating the adenosine 2B receptor (A2BAR). Meanwhile, activated A2BAR has the potential to enhance ENaC-dependent alveolar fluid clearance (AFC). However, whether netrin-1 can increase ENaC-mediated AF...

STUDY QUESTION What is the effect of different alkylating agents used without pelvic radiation to treat childhood cancer in girls on the ovarian reserve in survivors? SUMMARY ANSWER Ovarian reserve seems to be particularly reduced in survivors who received procarbazine (in most cases for Hodgkin lymphoma) or high-dose chemotherapy; procarbazine but not cyclophosphamide dose is associated with...

INTRODUCTION Operative laparoscopy is the most common used technique for treatment of patients with ovarian endometriomas, because of many positive effects in comparison with laparotomy. There are many laparoscopic techniques, but most used are cystectomy and puncture with endocoagulation (ablation) of the cyst's capsule. The aim of this study was to evaluate the effect of two laparoscopic tech...

The production of a modern biotechnology product, frequently a recombinant protein, requires a multistage downstream process because the feedstock is usually a liquid that is dilute in product concentration and contains many impurities some of which are unknown chemical compounds. Such a process typically centers on two or more liquid chromatography steps in order to achieve the desired purity....

The rearing period has a key influence on the later performance of cattle, affecting future fertility and longevity. Producers usually aim to breed replacement heifers by 15 months to calve at 24 months. An age at first calving (AFC) close to 2 years (23 to 25 months) is optimum for economic performance as it minimises the non-productive period and maintains a seasonal calving pattern. This is ...