Cancer cells undergo reprogramming of glucose metabolism to limit energy production to glycolysis-a state known as "aerobic glycolysis." Hypoxia-inducible factor 1 (HIF1α) is a transcription factor that regulates many genes responsible for this switch. As discussed here, new data suggest that the tumor suppressor WW domain-containing oxidoreductase (WWOX) modulates HIF1α, thereby regulating thi...

Cancer cells become dependent on aerobic glycolysis to sustain rapid proliferation and escape apoptosis. How this metabolic change, also known as the Warburg effect, is linked to apoptosis remains largely unknown. Our new data place c-Jun N-terminal kinase in the center of a hub regulating apoptosis and cancer metabolism.

Resistance (muscle strengthening) exercise is a key component of exercise recommendations for weight control yet very little is known about the effects of resistance exercise on appetite. We investigated the effects of resistance and aerobic exercise on hunger and circulating levels of the gut hormones acylated ghrelin and peptide YY (PYY). Eleven healthy male students: age 21.1 ± 0.3 y, body m...

Resistance (muscle strengthening) exercise is a key component of exercise recommendations for weight control, yet very little is known about the effects of resistance exercise on appetite. We investigated the effects of resistance and aerobic exercise on hunger and circulating levels of the gut hormones acylated ghrelin and peptide YY (PYY). Eleven healthy male students: age 21.1 +/- 0.3 yr, bo...

Although it is widely accepted that mitochondria play fundamental roles in the mechanisms of cellular and organismal aging and lifespan extension, some open questions remain concerning the requirements for aerobic energy production and the effect of the potentially hazardous reactive oxygen species (ROS) byproducts as well as their interplay with nutrition and caloric intake.

Abstract Telescopic water intake structures play an important role in a management system. The article is devoted to the improvement of telescopic and development solution for regulating their operation. Different types intakes are analyzed, shortcomings identified. known reviewed, operating principles analyzed. It has been determined that design existing lacks device stopping operation water. ...

Mammals that hibernate (hibernators) exhibit a circannual rhythm of food intake and body mass. In the laboratory during the winter hibernation period, many hibernators enter a series of multi-day torpor bouts, dropping their body temperature to near ambient, and cease to feed even if food is present in their cage. The mechanism(s) that regulates food intake in hibernators is unclear. Recently, ...

Background and Objective: The purpose of this study was to investigate the preconditioning effect of aerobic exercise with vitamin D3 consumption on vascular endothelial growth factor (VEGF) level in the 6-hydroxydopamine (6-OHDA)-lesioned rat model of Parkinson’s disease. Materials and Methods: Forty-eight male rats weighing 250-300 g were randomly assigned to 6 groups: healthy control, Parkin...

ABSTRACT: Objctive: Fructose consumption has increased worldwide. Excessive fructose intake been a risk factor for the metabolic syndrome disorder incidence. This study aimed to investigate possible influence of two different exercise training methods, continuous and interval, on intake. Methods: Thirty two-months-old female Wistar rats were divided into six groups: sedentary + water ; interval...