Epstein–Barr virus (EBV) is the prototypic human tumor whose continuous lifelong immune control required to prevent lymphomagenesis in more than 90% of adult population that are healthy carriers virus. Here, we review recent evidence this has not only target latent oncogenes, but also lytic replication EBV. Furthermore, genetic variations identify molecular machinery cytotoxic lymphocytes as es...

objective(s): progestrone is a prequisite for pre-implantation angiogenesis and induce decidual angiogenesis. it is unknown the effect of progestrone administration on the endometrium of hyperstimulated mice at pre-implantation time. material and methods: adult female nmri mice were divided in three groups [control group, ovarian stimulated group and progestrone treated mice after ovarian stimu...

introduction: idiopathic pulmonary fibrosis (ipf) is a relentlessly progressive and usually fatal lung disease of unknown etiology for which no effective treatments currently exist. in the adults type i and ii pneumocytes, forms components of the alveolar epithelial cells. in this study, we investigated the effect of thalidomide on the alveolar epithelial cells (type i and ii pneumocytes) in th...

background: stanozolol (st) is a synthetic anabolic-androgenic steroid often abused by athletes. an increasing body of evidence points towards the role of st misuses in the pathogenesis of a wide range of adverse effects including reprotoxicity. objective: the aim of this study was to analyze the possible reproprotective effect of royal jelly (rj) as an efficient antioxidant in st-treated mice....

Background: Acrylamid (AA) is found in carbohydraterich foods that are prepared at high temperatures, such as French fries and potato chips. The toxic effects of AA in male animals include degeneration of epithelial cells of seminiferous tubules, decreased number of sperm and elevation in abnormal spermatozoa. The aim of this study was to evaluate the detrimental effects of AA on sperm paramete...

Diabetic neuropathy is the loss of sensory function beginning distally in lower extremities, which also characterized by pain and substantial morbidity. Furthermore, locus coeruleus (LC) nucleus has been proposed to play an important role descending control through activation α2-noradrenergic (NA) receptors spinal dorsal horn. We studied, on diabetic mice, effect electrical stimulation LC tacti...

Evidence suggests that nicotine and alcohol can each serve as a gateway drug. We determined whether prior treatment would alter amphetamine reward. Also, we examined age dopaminergic neurotransmission are important in this regard. Male female adolescent adult C57BL/6J mice were tested for baseline place preference. Mice then received six conditioning with saline/nicotine (0.25 mg/kg) twice dail...