Multiple observations support the existence of developmental differences in megakaryocytopoiesis. We have previously shown that neonatal MK progenitors are hyperproliferative, and give rise to MKs smaller and of lower ploidy than adult MKs. Based on these characteristics, neonatal MKs have been considered immature. The molecular mechanisms underlying these differences are unclear, but contribut...

Multiple observations support the existence of developmental differences in megakaryocytopoiesis. We have previously shown that neonatal megakaryocyte (MK) progenitors are hyperproliferative and give rise to MKs smaller and of lower ploidy than adult MKs. Based on these characteristics, neonatal MKs have been considered immature. The molecular mechanisms underlying these differences are unclear...

The present contribution reviews evidence that supports the relevance of childhood antecedents of personality disorders, and advocates that the validity of a Five-Factor Model framework for describing general trait differences in childhood can be extended towards the field of developmental personality difficulties. In addition, we suggest that several traditional childhood Axis I conditions inc...

CONTEXT Most adults with a psychiatric disorder first met diagnostic criteria during childhood and/or adolescence, yet specific homotypic and heterotypic patterns of prediction have not been firmly established. OBJECTIVE To establish which childhood and adolescent psychiatric disorders predict particular young adult disorders when accounting for comorbidities, disaggregating similar disorders...

The role of clinical psychiatry today is to contribute to a “dynamic view” of biological, psychopathological and social factors. Indeed, in the light of recent contributions of gene-environment interaction 1, a growing body of interest is emerging from concepts as risk factors, traumas, protective factors and resilience 2. In particular, studies on early adversities have lead to an increasing i...

Dystonia in childhood may be severely disabling and often unremitting and unrecognized. Considered a rare disorder, dystonic symptoms in childhood are pervasive in many conditions including disorders of developmental delay, cerebral palsy (CP), autism, neurometabolic, neuroinflammatory, and neurogenetic disorders. Collectively, there is a need to recognize the role of early postures and movemen...

Background Neuromuscular disorders (NMD) such as Duchenne Muscular Dystrophy (DMD) are characterised by slow progressive muscle atrophy and weakness [1]. Weak respiratory muscles, loss of ambulation and mechanical factors, cause a reduction in total lung capacity (TLC) and Vital Capacity (VC). Patients are at risk of developing acute conditions that decrease pulmonary function and in turn trigg...

27 X-linked ichthyosis (XLI) is a rare dermatological condition arising from deficiency for the enzyme 28 steroid sulfatase (STS). Preliminary evidence in boys with XLI, and animal model studies, suggests that 29 individuals lacking STS are at increased risk of developmental disorders and associated traits. 30 However, the behavioural profile of children with XLI is poorly-characterised, and th...

Background: Prematurity is the most common cause of death and disability And Preterm infants, are prone to developmental complications. For this reason this study was designed for follow up of these babies until 2 years by modified DDST-2. Methods: This study was a prospective longitudinal descriptive study from March 2009 to March 2011 in clinic of sheikh and Imam Reza Hospitals, mashhad, Iran...

At an estimated prevalence of up to five percent in the general population, fetal alcohol spectrum disorders (FASD) are most common neurodevelopmental disorder, at least if not more prevalent than autism (2.3%). Despite this pediatricians and other developmental specialists have thus far failed diagnose disability, leaving children adults without supports provided for disabilities. This paper w...