The clinical application of adriamycin, an exceptionally good chemotherapeutic agent, is limited by its dose-related cardiomyopathy. Our recent study showed that tumor necrosis factor-alpha (TNF-alpha) receptors mediated cytoprotective signaling against adriamycin-induced mitochondrial injury and cardiomyocyte apoptosis. In the present study, we investigated the potential targets of TNF recepto...

There is considerable interest in the skin as a site of anti-cancer drug application. Nevertheless, the skin poses a formidable barrier to drug penetration, thereby limiting topical and transdermal bioavailability. However, we previously showed that a thioglycolate-based depilatory agent increases the drug permeability of mouse skin. In the present report, we investigated the skin permeability ...

We have evaluated the degree to which hepatic arterial infusion of Adriamycin produces higher hepatic and lower systemic drug concentrations than are achieved with corre sponding peripheral venous infusion. Hepatic arterial catheters were placed in seven patients with primary or metastatic liver cancer. Temporary hepatic venous catheter placement allowed direct sampling of drug levels in the he...

The effects of whole-body hyperthermia on the disposi tion and metabolism of Adriamycin were investigated in male New Zealand rabbits. Hyperthermia [rectal temper ature, 42.3 ±0.1°(S.D.)] was produced in nonacclimatized, unrestrained animals by placing them in a humidity (95%)and temperature (34 )-regulated chamber. Normothermic controls (rectal temperature, 39.7 ±0.1°)were maintained at am...

The reduction of ferricytochrome c with adriamycin in phospate buffered saline (pH 7.4) and alkaline solution was obsereved spectrophotometrically. The reduction increased gradually with time of incubation, and decreased with the addition of superoxide dismutase. The semiquinone radical derived from adriamycin was detected by electron spin resonance spectrometer. Superoxide production by analog...

The lymphatic absorption and tissue distribution of free [14C]Adriamycin, "empty" [3H]liposomes, free [14C]Adriamycin plus empty [3H]liposomes, and [14C]Adriamycin entrapped into [3H]liposomes have been examined at intervals after i.p. injection into rats. Following treatment with empty [3H]liposomes, almost 30% of the liposomal lipid marker was recovered in 24-hr thoracic duct lymph, but when ...

Abstract Background Cancer is the leading cause of morbidity and mortality worldwide. It encompasses a large family diseases exhibiting abnormal cell growth with potential to invade or spread other part body. Natural extracts have been used as an efficient anticancer agent that show promising results. In this, study cytotoxicity effect Ayurvedic herbal extract code name V2S2 was studied compare...

The antitumor drug Adriamycin, when preincubated with hu man red blood cells (discocytes) for 10 min, prevented the formation of echinocytes induced by the calcium ionophore A23187 in the presence of 0.2 rriM calcium. The degree of protection was concentration dependent and was >90% at 10 UM Adriamycin. Adriamycin did not interfere with the accumula tion of calcium induced by a 5 MMconcentratio...

We have evaluated the degree to which hepatic arterial infusion of Adriamycin produces higher hepatic and lower systemic drug concentrations than are achieved with corre sponding peripheral venous infusion. Hepatic arterial catheters were placed in seven patients with primary or metastatic liver cancer. Temporary hepatic venous catheter placement allowed direct sampling of drug levels in the he...

First-step Adriamycin (doxorubicin)-resistant mutants of the murine erythroleukemia cell line PC4 were cloned from Adriamycin-containing (10 ng/ml) methylcellulose at a frequency of 3 x 10(-4). They demonstrated 1.6- to 2.4-fold stable resistance to Adriamycin. Most were cross-resistant to etoposide, but not to vincristine, and were without enhanced expression of mdr genes, which code for P-gly...