Hodgkin disease (HD) is characterized by a small number of malignant Hodgkin and Reed-Sternberg (H/RS) cells among a major population of nonmalignant cells. The analysis of H/RS cells has been hampered by their low frequency and fragility. Here, we describe the isolation of viable H/RS cells from HD affected tissues by high gradient magnetic cell sorting (MACS) according to expression of CD30. ...

We investigate the association between phosphorylated histone H3 (PhH3) and Oncotype DX recurrence score (RS). All invasive breast carcinoma with RS results from our city between 2007 and 2010 (n=47) were reviewed. Whole-tumor sections were stained for PhH3. Mitotic and PhH3 counts were performed and clinical charts reviewed. PhH3 correlated well with RS (r=0.69, P<0.001). Other correlations we...

Glutamate is recognized as a prominent excitatory transmitter in the supraoptic nucleus (SON) and is involved in transmission of osmoregulatory information from the osmoreceptors to the vasopressin (VP) and oxytocin (OT) neurons. Explants of the hypothalamo-neurohypophysial system were utilized to characterize the roles of the non-N-methyl-D-aspartate (NMDA) glutamate receptor subtypes (non-NMD...

PURPOSE The Oncotype DX assay predicts likelihood of distant recurrence and improves patient selection for adjuvant chemotherapy in estrogen receptor-positive (ER-positive) early stage breast cancer. This study has two primary endpoints: to evaluate the impact of Oncotype DX recurrence scores (RS) on chemotherapy recommendations and to compare the estimated recurrence risk predicted by breast o...

?By E. B. Jamieson, M.D. Sections I to V. Section I:? Central Nervous System. (Contains 48 plates.) Section II:?Head and Neck. (Contains 61 plates.) Section III:?Abdomen. (Contains 37 plates.) Section IV:?Pelvis. (Contains 30 plates) and Section V:?Thorax. (Contains 27 plates.) 1934. E. and S. Livingstone, Edinburgh. Obtainable from Messrs. Butterworth and Company (India), Limited, Calcutta. Pr...

Roberto Giugliani and Ursula Matte Serviço de Genética Médica, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil. Departmento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. Instituto Nacional de Genética Médica Populacional, Porto Alegre, RS, Brazil. Programa de Pós-Graduação em Genética e Biologia Molecular, Universidade Federal do Rio Grande do ...

The author reviews the issue on whether Rett syndrome (RS) is a subtype of pervasive developmental disorders (PDDs). More than 200 articles of RS have been published in the last 10 years. Internal and external validities of RS have been established by several independent studies. There remains the question whether RS presents clinical features that meet the total criteria for PDDs. The availabl...

Luciele Medianeira Schifelbain, Silvia Regina Rios Vieira, Janete Salles Brauner, Deise Mota Pacheco, Alexandre Antonio Naujorks I Intensive Care Unit, Hospital de Caridade Dr. Astrogildo de Azevedo, Santa Maria, RS, Brazil. II Intensive Care Unit, Hospital de Clı́nicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil. III Intensive Care Unit, HCPA, Porto Alegre, RS, Brazil; Hospital Nossa Senho...

The ARIDFLO project takes a multi-disciplinary approach to the collection and analysis of data required to formulate appropriate environmental flow requirements for rivers in the Lake Eyre Basin. The key drivers of the ecological processes underpinning the health of these rivers are identified by modelling wholeof-ecosystem biological responses to hydrological events over a range of spatial and...

Historically, the use of animals for research has been important in the biomedical sciences and in the field of toxicology, but there are ethical obligations on the scientific community to follow the Three Rs of animal experimentation1 (i.e. Refinement, Reduction and Replacement), whenever it is feasible. There are also scientific, economic and regulatory restrictions, as well as societal conce...