The aim of the study was to compare self-reported and analytically confirmed substance use in cases of acute recreational drug toxicity.We performed a retrospective analysis of emergency department presentations of acute recreational drug toxicity over 2 years (October 2013 to September 2015) within the European Drug Emergencies Network Plus project.Among the 10,956 cases of acute recreational ...

Acute toxicity is manifested in terms of effects which occur after a single administration or relatively brief exposure to substance mixture. The evidence for acute usually obtained from animal testing so characterised lethality and times used experimental protocols. Mainly two hazardous classes are reported that known as “Acute toxicity” “STOT-SE (Specific Target Organ Toxicity-Single Exposure...

conclusions the present study provides the first experimental evidence in support of dexmedetomidine treatment for cocaine-induced seizures. premedication with dexmedetomidine reduces seizure activity in a mouse model of acute cocaine toxicity. in addition, while dexmedetomidine may be effective, moxonidine and alpha-methyldopa did not effectively prevent cocaine-induced lethality. results the ...

Background: Herbicides are widely used in agriculture to kill a large variety of unwanted weeds. However, the application in water ecosystems may pose harmful impacts on the health of aquatic organisms. We studied the acute toxicity of four major types of herbicides on the survival of adult shrimp, Artemia franciscana (AF). Methods: The brine shrimp, AF, was hatched from the commercially encys...

abstract background and objective: iranian traditional medicine (itm) has a long history in the prevention and treatment of diseases. clinical uses, side effects, and toxic effects of many singular and compounds were known to scientists of itm and articular books on toxicology and detoxification of drugs has been written by scientists, but their measurement tools to evaluate chronic toxicity of...

The purposes of acute toxicity testing are to obtain information on the biologic activity of a chemical and gain insight into its mechanism of action. The information on acute systemic toxicity generated by the test is used in hazard identification and risk management in the context of production, handling, and use of chemicals. The LD50 value, defined as the statistically derived dose that, wh...

Abstract Background and Objective: Iranian Traditional Medicine (ITM) has a long history in the prevention and treatment of diseases. Clinical uses, side effects, and toxic effects of many singular and compounds were known to scientists of ITM and articular books on toxicology and detoxification of drugs has been written by scientists, but their measurement tools to evaluate chronic toxicity of...

Recently nanoparticles, particularly silver nanoparticles, are broadly used in industry, hence the contamination of the environment with AgNPs has caused considerable concern. In this study, the toxicity of biosynthetic nanosilver produced by two macroalgae: Sargassum boveanum and Ulva flexuosa extracts were compared with chemical nanosilver in Daphnia magna. Size and quality of nanoparticles e...

Background: In recent years, neoadjuvant chemoradiation and subsequent surgical resection with total mesorectal excision has been shown to increase local control with decreased toxicity. Neoadjuvant chemoradiotherapy is the standard treatment for locally advanced rectal cancer. In this study we evaluated the efficacy a cox-2 inhibitor on pathologic response, sphincter preservation and acute tox...