BACKGROUND Low values of estimated glomerular filtration rate (eGFR) predispose to acute kidney injury, and proteinuria is a marker of kidney disease. We aimed to investigate how eGFR and proteinuria jointly modified the risks of acute kidney injury and subsequent adverse clinical outcomes. METHODS We did a cohort study of 920,985 adults residing in Alberta, Canada, between 2002 and 2007. Par...

We present a case of severe cardiovascular emergency in 21-year-old patient — malignant hypertension complicated by acute kidney injury and thrombotic microangiopathy.

Background: Acute kidney injury (AKI) is a common complication associated with cardiac surgery cardiopulmonary bypass (CPB) deleterious effect on morbidity and mortality. The current st...

The inflammatory response has been shown to be a major contributor to acute kidney injury. Considering that laparoscopic surgery is beneficial in reducing the inflammatory response, we compared the incidence of postoperative acute kidney injury between laparoscopic liver resection and open liver resection. Among 1173 patients who underwent liver resection surgery, 222 of 926 patients who underw...

Autophagy is induced in renal tubular cells during acute kidney injury; however, whether this is protective or injurious remains controversial. We address this question by pharmacologic and genetic blockade of autophagy using mouse models of cisplatin- and ischemia-reperfusion-induced acute kidney injury. Chloroquine, a pharmacological inhibitor of autophagy, blocked autophagic flux and enhance...

INTRODUCTION Acute kidney injury is a rare and sometimes fatal complication of pregnancy, the incidence of which has been declining worldwide, though still high in developing countries. There are recent observations of increasing incidence in some developed countries attributed to hypertensive disorders of pregnancy. MATERIALS AND METHODS In this study, we have analysed the records of all pat...

See the article "Electronic alert outpatient protocol improves quality of care for risk postcontrast acute kidney injury following computed tomography" in Volume 42 on page 606.

OBJECTIVE Evaluating the effect of preconditioning with simvastatin in acute kidney injury induced by sepsis. METHOD Male adult Wistar rats were divided into the following groups: SHAM (control); SHAM+Statin (0.5 mg/kg simvastatin, orally); Sepsis (cecal puncture ligation - CPL); Sepsis+Statin. Physiological parameters, peritoneal fluid culture, renal function, oxidative metabolites, severity...