U.v. irradiation of SH-RP cells, a lymphoblastoid cell line carrying EpsteinBarr virus, which was derived from a patient with acute myeloid leukaemia, retarded cell growth but significantly enhanced the percentage of cells containing virus-capsid antigen (VCA) as demonstrated by indirect immunofluorescence. The effects of u.v. irradiation on SH-RP cultures were reversible under normal condition...

OBJECTIVE To determine whether second whole-brain irradiation is beneficial for patients previously treated with whole-brain irradiation. METHODS A retrospective analysis was done for 31 patients with brain metastases who had undergone re-irradiation. Initial whole-brain irradiation was performed with 30 Gy/10 fractions for 87% of these patients. Whole-brain re-irradiation was performed with ...

Children with ataxia telangiectasia have a high probability of developing acute lymphoblastic leukaemia, and have increased sensitivity to chemotherapy and irradiation. We report a 51/2 year old boy who had undiagnosed ataxia telangiectasia when he presented with acute lymphoblastic leukaemia. He subsequently developed a chemoradiation induced leukoencephalopathy after conventional central nerv...

Introduction: Nasopharyngeal carcinoma (NPC) is commonly known as a radiosensitive tumor with the initial good response to radiation. Despite the improved outcome in loco regional control by the introduction of combining treatment, modern radiotherapy techniques and enhanced imaging studies, local recurrent after primary treatment with rate ranges from 15-58% in 5 years, stil...

To retrospectively evaluate the performance and complications of postmastectomy intensity modulation radiated therapy (IMRT) technique.From January 2010 to December 2014, IMRT technique was applied to 200 patients after modified radical mastectomy. The acute and late radiation toxicities have been followed up for 5 years. The treatment performance, toxicity incidence, and risk factors were inve...

introduction: laser phototherapy is used for the treatment of chemotherapy-induced oral mucositis in patients with leukemia, although there are limited data supporting the safety of this method. this study aimed to evaluate the effect of different doses of low-level laser on proliferation of acute myeloid leukemia (aml) cell line (kg-1a) in vitro. methods: a plastic flask containing 5,000,000 k...

Two separate lines of evidence suggested the present study. First, intracerebroventricularly (i.c.v.) administered morphine (a μ-opioid receptor agonist) and β-endorphin (an ε-opioid receptor agonist) produce antinociception by activating different descending pain inhibitory systems. Second, γ-irradiation attenuates the acute antinociceptive action of i.c.v. injected morphine, but not DPLPE (a ...

BACKGROUND AND PURPOSE Currently, no readily available mitigators exist for acute abdominal radiation injury. Here, we present an animal model for precise and homogenous limb-sparing abdominal irradiation (LSAIR) to study the radiation-induced gastrointestinal syndrome (RIGS). MATERIALS AND METHODS The LSAIR technique was developed using the small animal radiation research platform (SARRP) wi...

Chemical exchange saturation transfer (CEST) imaging provides a unique contrast through the exchange between solute protons and bulk water protons 1. It can detect tissue acidosis and elevated protein content in acute ischemia and animal tumor models 2,3. Conventionally, a continuous wave (CW) RF pulse is applied at the solute proton frequency and the saturation is transferred to the bulk water...

OBJECTIVE Endothelial dysfunction and vascular dysregulation contribute to the pathological effects of radiation on tissues. The objectives of this study were to assess the acute effect of irradiation on acetylcholine (Ach)-induced dilation of gut submucosal microvessels. METHODS AND RESULTS Rats were exposed in vivo to 1 to 9 cGy in 3 fractions per week on alternate days for 3 successive wee...