1. Bone formation in the rabbit kidney with ligated vessels takes place (a) through the activity of young fibroblasts which accumulate to form a membrane-like structure; (b) subsequently by direct ossification of hyaline connective tissue in continuity with preformed bone; and (c) through erosion of lime placques by granulating tissue and laying down of lamellar bone by cells derived from fibro...

Background: Osteoporosis one of the postmenopausal symptoms is characterized by bone loss. There is a link between excessive reactive oxygen species (ROS) formation, estrogen deficiency due to cessation of ovarian function and bone loss. Free radicals are responsible for causing osteoblast apoptosis and reducing osteoblastogenesis in bone remodeling. Vitamin E is a potent antioxidant with the a...

Tumor cells in the bone microenvironment are able to initiate a vicious cycle of bone degradation by mobilizing osteoclasts, multinucleated cells specialized in bone degradation. c-Src is highly expressed both in tumors and in osteoclasts. Therefore, drugs like AZD0530, designed to inhibit Src activity, could selectively interfere with both tumor and osteoclast activity. Here we explored the ef...

Miljanka VUKSANOVIĆ Kliničko odeljenje za endokrinologiju, dijabetes i bolesti metabolizma Interna klinika Kliničko-bolnički centar „Zvezdara“ Dimitrija Tucovića 161 11000 Beograd Srbija [email protected] SUMMARY Bone is a living tissue, metabolically very active, with the level of turnover of about 10% per year. Bone remodeling is a well-balanced process of bone resorption, induced by osteoc...

Osteoporosis or porous bone was first described by Fuller Albright approximately 70 years ago as having “too little bone in the bone”. Bone tissue is maintained throughout life by being continually replaced and in osteoporosis bone resorption exceeds bone formation resulting in bone loss. The majority of current treatments for osteoporosis are antiresorptive, decreasing osteoclast activity and ...

Ossifying fibroma (osteofibrous dysplasia) is a rare fibro-osseous lesion made up of fibrous tissue with woven bone formation. It is most commonly found in the tibia and fibula of children ten years of age or younger. The most important differential diagnosis is monostotic fibrous dysplasia, which is radiologically similar but without woven bone rimmed by active osteoblasts like ossifying fibro...

Indian hedgehog (Ihh) signaling is indispensable for osteoblast differentiation during endochondral bone development in the mouse embryo. We have previously shown that the Gli2 transcription activator critically mediates Ihh function in osteoblastogenesis. To explore the possibility that activation of Hedgehog (Hh) signaling may enhance bone formation, we generated mice that expressed a constit...

Brain-derived neurotrophic factor (BDNF), which is released due to nerve injury, is known to promote the natural healing of injured nerves. It is often observed that damage of mandibular canal induces local sclerotic changes in alveolar bone. We reported that peripheral nerve injury promotes the local production of BDNF; therefore, it was possible to hypothesize that peripheral nerve injury aff...

We have previously shown that idiopathic juvenile osteoporosis (IJO) is characterized by a decreased cancellous bone volume and a very low bone formation rate on cancellous surfaces. Whether IJO similarly affects cortical bone is unknown. We therefore compared tetracycline double-labeled transfixing iliac-crest bone biopsies from eight children with typical clinical features of IJO (six girls; ...

The carotene p-hydroxycinnamic acid and the xanthophyll β-cryptoxanthin are members of the carotenoid family of plant-derived pigments, which are endowed with anti-osteoporotic properties in vivo. p-Hydroxycinnamic acid and β-cryptoxanthin have been demonstrated to stimulate osteoblastic bone formation while simultaneously repressing osteoclastic bone resorption in vitro. However, their mechani...