Glutamine phosphoribosylpyrophosphate amidotransfer ase (amidophosphoribosyltransferase, EC 2.4.2.1 4) from normal rat liver and rapidly growing Morris hepatoma 3924A has been purified 1622-and 1224-fold, respectively. Acryl amide gel electrophoresis demonstrated that the purified amidotransferase from liver and hepatoma had the same mobility. Kinetic studies established that the purified en zy...

Purpose: To formulate and evaluate pH-sensitive controlled release cefixime microspheres based on crosslinked chitosan and acryl amide-grafted-poly ethylene glycol Method: pH sensitive interpenetrating network (IPN) cefixime microspheres based on chitosan, its grafted copolymer, and hydrolyzed grafted copolymer were prepared by precipitation and crosslinking methods. The formulations were chara...

The synthesis and spectroscopic characterization of the glutaric acid-amide derivative, 2,4-Cl2C6H3N(H)C(=O)(CH2)3C(=O)OH (1), are described. X-ray crystal structure determination (1) shows backbone molecule to be kinked about methylene-C–N(amide) bond as seen in C(p)–N–C(m)–C(m) torsion angle ?157.0(2)°; m = methylene p phenyl. An additional twist is noted between amide phenyl groups reflected...

In the title compound, C(11)H(9)NO(2), the mean planes formed by the phenyl and acryl group are almost orthogonal to each other, with a dihedral angle of 88.61 (7)°. The carbonitrile side chain is almost linear, the C-C-N angle being 179.54 (16)°. In the crystal, mol-ecules are linked by inter-molecular O-H⋯O inter-actions into infinite chains running parallel to the b axis.

The vitreous body has become an interesting location for the administration of injections or implants in modern ophthalmology. Such intravitreal dosage forms are loaded with active agents which are released over a prolonged period of time. A test method simulating the in vivo situation is needed to observe the release behaviour of these new dosage forms and the distribution of drug substances i...

A new simple and reliable method for rapid and selective extraction and determination of trace levels of Zn(II) ion is developed. Zn(II) ions are adsorbed quantitatively during passage of aqueous samples through PET-AA/AAm nano fiber modified. Almost all matrix elements were found to pass through the nano fiber to drain. Modified Poly (ethylene terephthalate)-grafted-Acrylic acid/Acryl amide Na...

A new simple and reliable method for rapid and selective extraction and determination of trace levels of Zn(II) ion is developed. Zn(II) ions are adsorbed quantitatively during passage of aqueous samples through PET-AA/AAm nano fiber modified. Almost all matrix elements were found to pass through the nano fiber to drain. Modified Poly (ethylene terephthalate)-grafted-Acrylic acid/Acryl amide Na...