Respiration-deficient mutants (Rho-, petite) of Saccharomyces carlsbergensis were obtained by treatment with trypaflavin (euflavine). Dried cells of these mutants phosphorylated mononucleotides to their triphosphates and further formed not only cytidine 5'-diphosphate-choline, but also sugar nucleotides, such as uridine 5'-diphosphate-glucose, guanosine 5'-diphosphate-mannose, etc. The activiti...

In 12 B-lactamase producing strains of N gonorrhoeae tested, the coding for enzyme production was sensitive, to varying degrees, to one or more of the three agents ethidium bromide, acridine orange, or acriflavine. The substances tested were able to eliminate the plasmid responsible for B-lactamase production but the time required varied. The Far East type of gonococci (plasmid 4.4 Md) were cur...

in some detail, with the aid of several figures, followed by chapters on stereoscopic localisation, tetanus, gas gangrene and wounds of the head, chest, joints and abdomen. In no case do the chapters pretend to completeness; they are merely notes on recent improvements in methods. The " Ambrine " treatment of burns is dealt with, and the newest antiseptics?Dichloramin-T, Acriflavine, and Brilli...

T-lymphocytes prepared from the peripheral blood of normal individuals exhibit uniform postmitotic DNA contents that are constant from individual to individual when fixed in ethanol and stained with mithramycin, or when fixed in formalin and stained with acriflavine-Feulgen and analyzed by flow microfluorometry. T-lymphocytes fixed by either method are stable on storage for several months. Thes...

Malaria continues to be a major health problem globally. There is an urgent need to find new antimalarials. Acriflavine (ACF) is known as an antibacterial agent and more recently as an anticancer agent. Here, we report that ACF inhibits the growth of asexual stages of both chloroquine (CQ) sensitive and resistant strains of human malarial parasite, Plasmodium falciparum in vitro at nanomolar co...