The development or ripening of the oocyst of the coccidium of the rabbit is prevented by acridine hydrochloride provided that the cysts are exposed to the action of the chemical before development has started. After sporoblasts are formed acridine does not prevent further development. Many other substances, some of them known to be active against certain protozoan parasites, have no influence o...

The synthesis and biological evaluation of a series of bifunctional acridine-HSP90 inhibitor ligands as telomerase inhibitors is herein described. Four hybrid acridine-HSP90 inhibitor conjugates were prepared using a click-chemistry approach, and subsequently shown to display comparable results to the established telomerase inhibitor BRACO-19 in the TRAP-LIG telomerase assay. The conjugates als...

A new fluorescent acridine orange derivative, 3-amino-6-methoxy-9-(2-hydroxyethylamino) acridine (AMHA), has been applied to Hela cells in order to set up appropriate conditions for the detection of mycoplasma contaminations. Since AMHA staining reveals intensely fluorescent nuclei and slight fluorescent cytoplasm, we can visualize and localize mycoplasma contamination on each cell. In combinat...

The double-stranded helical structure of DNA is maintained in part by hydrogen bonds between strands and by stacking interactions between adjacent purine and pyrimidine bases in one strand. The transition (denaturation) from a double-stranded (ds) to a single-stranded (ss) form can be induced in isolated DNA or fixed cells by exposure to elevated temperatures, alkali or acids, aprotic or nonpol...

The title compound C25H29BrClNO4, comprises a 3,3,6,6-tetra-methyl-tetra-hydro-acridine-1,8-dione ring system that carries a hy-droxy-ethyl substituent on the acridine N atom and a 3-bromo-5-chloro-2-hy-droxy-phenyl ring on the central methine C atom of the di-hydro-pyridine ring. The benzene ring is inclined to the acridine ring system at an angle of 89.84 (6)° and this conformation is stabili...

Present work describes the fluorescence spectroscopy determination of (6-TG) using silver nanoparticles (AgNPs). The acridine could be electrostatically adsorbed to the surface of the citrate-stabilized silver nanoparticles. Upon addition of 6-TG, the acridine is replaced from the surface of AgNPs which induce the aggregation of AgNPs. Under optimum condition, the fluorescence intensity enhance...

Materials with large non-linear optical properties are good candidates for applications in the fields of telecommunications, solar energy conversion, laser treatment and so on. In the present study, a crystal of Ammonium Dihydrogen Orthophosphate doped with Acridine Orange, possessing excellent nonlinear optical properties were grown by the slow solvent evaporation technique at 25 ̊C using a con...

In the crystal structure of the title compound, C(21)H(15)FNO(2) (+)·CF(3)SO(3) (-), the cations form inversion dimers through C-H⋯O, C-F⋯π and π-π inter-actions. These dimers are further linked by π-π inter-actions. The cations and anions are connected through C-H⋯O, C-F⋯π and S-O⋯π inter-actions. The acridine and benzene ring systems are oriented at a dihedral angle of 74.1 (1)°. The carboxyl...

The fluorescence technique described here utilizes the electrostatic interaction between the polyanionic sites of glycosaminoglycans and the cationic dye Acridine Orange to analyse urinary glycosaminoglycans from patients suffering from mucopolysaccharidoses. The basis of the titration is the decrease in the fluorescence of free Acridine Orange that occurs when it is bound to polyanions. The ef...

The sensitivity of quinolineand acridine-type indicators towards the detection of low levels of chloride ions in aqueous and amine-doped media, by fluorescence quenching, is reported in this paper. Solution studies are based on the fluorescence of quinine sulphate, acridine and 3(6-methoxyquinolino) propanesulphonate (SPQ) and the fluorescence response of these indicators has been examined at d...