نتایج جستجو برای: aconitine
تعداد نتایج: 298 فیلتر نتایج به سال:
Background: Enhancement of cerebrocortical GABAergic inhibition is postulated as the main mechanism by which anesthetics inhibit seizures; however this has not been directly tested under controlled conditions. In this study we utilized the isolated cerebral cortex slice preparation and tested the anticonvulsant properties of three anesthetics with differing specificities for GABAergic activatio...
OBJECTIVE To study the antiarrhythmic effect of remifentanil in experimental arrhythmias in dogs. METHODS We used dogs weighing 12 kg-18 kg anesthetized with 30 mg/kg sodium pentobarbital given intravenously. Ventricular arrhythmia, ventricular fibrillation and death were induced with digoxin (9 microg/kg/min). In another model, two types of arrhythmia were induced in the right atrium, one of...
The anticonvulsants phenytoin and carbamazepine interact allosterically with the batrachotoxin binding site of sodium channels. In the present study, we demonstrate an autoradiographic technique to localize the batrachotoxin binding site on sodium channels in rat brain using [3H]batrachotoxinin-A 20-alpha-benzoate (BTX-B). Binding of [3H]BTX-B to brain sections is dependent on potentiating allo...
Several groups of drugs have been shown to possess antiarrhythmic activity. Some of them e.g. quinidine, procainamide, local anaesthetics, β-receptor blocking agents and diphenylhydantoin etc. have achieved a clinical status as antiarrhythmic drugs. Diphenyl hydantoin (dilantin) an anticonvulsant has been successfully employed for the supression of ventricular arrhythmias due to digitalis ...
BACKGROUND Ozone (O₃) is a well-documented respiratory oxidant, but increasing epidemiological evidence points to extrapulmonary effects, including positive associations between ambient O₃ concentrations and cardiovascular morbidity and mortality. OBJECTIVE With preliminary reports linking O₃ exposure with changes in heart rate (HR), we investigated the hypothesis that a single inhalation exp...
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