نتایج جستجو برای: acetylaspartate
تعداد نتایج: 2263 فیلتر نتایج به سال:
BACKGROUND AND PURPOSE Although NAA is often used as a marker of neural integrity and health in different neurologic disorders, the temporal behavior of WBNAA is not well characterized. Our goal therefore was to establish its normal variations in a cohort of healthy adults over typical clinical trial periods. MATERIALS AND METHODS Baseline amount of brain NAA, Q(NAA), was obtained with nonloc...
Hippocampal N-Acetylaspartate Concentration and Response to Riluzole in Generalized Anxiety Disorder
BACKGROUND AND PURPOSE Neuro-axonal damage is a well known sequelae of MS pathogeneses. Consequently, our aim was to test whether the ∼20% of patients with MS exhibiting a clinically benign disease course also have minimal neural dysfunction as reflected by the global concentration of their MR imaging marker NAA. MATERIALS AND METHODS Q(NAA) was obtained with nonlocalizing whole-head (1)H-MR ...
N-acetylaspartate (NAA) is an amino acid derivative present in high concentration in the brain. The function of NAA is still unsettled in spite of 50 years of research. The mainly neuronal synthesis and glial breakdown of NAA requires a well regulated neuronal efflux and glial uptake. In the present work hippocampal slices were used to study how NAA efflux from neurons is regulated and to furth...
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