3,4-Dihydropyrimidin-2(1H)-ones were synthesised in high yields by one-pot three-component Biginelli condensation in the presence of room temperature ionic liquids such as 1-n-butyl-3-methylimidazolium tetrafluoroborate (BMImBF4) or hexafluorophosphorate (BMImPF6) as catalysts under solvent-free and neutral conditions. © 2001 Elsevier Science Ltd. All rights reserved. Recently, the interest in ...

The lactating rabbit synthesizes milk triacylglycerol, which contains a high proportion (approx. 65 mo1/100mol) of medium-chain fatty acids, the remainder being long-chain fatty acids (Smith et al., 1968). Experiments in vivo with suckling rabbits had shown that medium-chain milk fatty acids were transported to the liver via the hepatic portal vein, and were taken up by the liver. In order to c...

The observation of a coenayme A (CoA)-catalyzed acetoacetate synthesis from acetate and adenosinetriphosphate in pigeon liver extracts (1) grouped this reaction with the larger family of acetylation reactions. Furthermore it furnished partial confirmation of an earlier calculation (2) showing that 16,000 calories are required for the condensation of two acetates to acetoacetate. Thus, one energ...

The aerobic dehydrogenation of the N-methyl group of sarcosine initiates an energy-requiring reduction of diphosphopyridine nucleotide in intact mitochondria. The formation of DPNH can be measured both spectrophotometrically and by the reduction of acetoacetate. Except in the presence of uncouplers, such as Dicumarol and arsenate, reduction of DPN by sarcosine does not require added adenosine t...

glucose 500 mg/L, acetoacetate 80 mgfL, bilirubin8 mg/L, hemoglobin 0.4mg/L, nitrite1 mg/L, and ascorbic acid 100 mgfL. The testsforproteinand ketones were more sensitive than the manufacLurer claims, throughout the range of concentrations studied, but for other analytes the expected results were obtamed. Abnormal urines submitted for unnalysis were collected, randomized, and analyzed with N-Mu...

The arteriovenous uptake differences for glucose, lactate, pyruvate, />'hydroxybutyrate, and acetoacetate were measured in vessels across squa mine, cell carcinomas in ten selected patients with tumors of the head and neck. All tumors measured took up glucose, pyruvate, 0-hydroxybutyrate, and acetoacetate. They could either produce, take up, or main tain a constant level of lactate. These tumor...

Although the literature contains studies published more than 30 years ago showing that acetone is not metabolically inert, it is common to find biochemistry textbooks and current research publications asserting that acetone is a 'dead-end' metabolite. In fact, acetone derived from the non-enzymatic breakdown of acetoacetate in ketotic individuals or from the oxidation of ingested isopropanol ca...

In the net reaction catalyzed by homogentisate oxidase of rat liver, two atoms of osygen are added to the double bond between carbon atoms 1 and 2 of homogentisate (2, 3) resulting in the formation of maleylacetoacetate (Fig. 1). The enzyme is located in the soluble phase of the liver cell; its activity is totally independent of the hydrogen and electron transport system. Its properties and mod...