Interindividual and interstrain variations in cholesterol absorption efficiency occur in humans and animals. We investigated physiological biliary and small intestinal factors that might determine variations in cholesterol absorption efficiency among inbred mouse strains. We found that there were significant differences in cholesterol absorption efficiency measured by plasma, fecal, and lymphat...

background: morpholine is a toxic substance used in industry and agriculture and can be absorbed into the body through ingestion, inhalation, and the skin. the present study aimed to assess the effect of morpholine and physiological serum ingestion on qualitative and quantitative characteristics of white blood cells and kidney tissue of white male mice. materials and methods: in the present stu...

It is believed that rare earth elements are not absorbed, and thus they are generally used in some mineral absorption studies as a faecal marker. The aim of the present study was to determine the effect of inulin intake and age on dysprosium (Dy) absorption in rats. Eighty male Wistar rats of four different ages (2, 5, 10 and 20 months) were randomised into either a control group or a group rec...

Several solutes are preferentially absorbed by specific segments of the gastrointestinal tract(l). This variation in the distribution of sites for particular absorptive meclhanisms suggests that the enzymes related to these processes may also be assymmetrically distributed. The observation that ouabain, an inhibitor of sodium-potassium-activated adenosine triphosphatase (Na-K-ATPase) in vitro, ...

We present a novel method for testing drug permeability that features human cells cultured on hydrogel scaffolds made to accurately replicate the shape and size of human small intestinal villi. We compared villous scaffolds to more conventional 2D cultures in paracellular drug absorption and cell growth experiments. Our results suggest that 3D villous platforms facilitate cellular differentiati...

Bile salts are ionic amphiphilic compounds with a steroid skeleton. Among the most important physiological properties of bile salts are lipid transport by solubilization and transport of some drugs through hydrophobic barriers. Bile salts have been extensively studied to enhance transepithelial permeability for different marker molecules and drugs. They readily agglomerate at concentrations abo...

At birth, the distal lung epithelium undergoes a profound phenotypic switch from secretion to absorption in the course of adaptation to air breathing. In this review, we describe the developmental regulation of key membrane transport proteins and the way in which epinephrine, oxygen, glucocorticoids, and thyroid hormones interact to bring about this crucial change in function. Evidence from mol...

Physiological control over iron balance is normally exercised through the regulation of iron absorption. Although it is known that the intestinal epithelium can reject unwanted dietary iron or absorb increased amounts when stores are low it is not known how iron crosses the epithelial cell or how this regulation is mediated. The principal factors which affect absorption are those acting in the ...

Physiological control over iron balance is normally exercised through the regulation of iron absorption. Although it is known that the intestinal epithelium can reject unwanted dietary iron or absorb increased amounts when stores are low it is not known how iron crosses the epithelial cell or how this regulation is mediated. The principal factors which affect absorption are those acting in the ...

Poor iron status affects billions of people worldwide. The prevalence of obesity continues to rise in both developed and developing nations. An association between iron status and obesity has been described in children and adults. The mechanism explaining this relationship remains unknown; however, findings from recent reports suggest that body mass index and inflammation predict iron absorptio...