5-[(4-carboxybutanoyl)amino]-2-hydroxybenzoic acid (C2) is a novel synthetic derivative of 5-aminosalicylic acid (5-ASA), which is currently being evaluated ex vivo as an anti-inflammatory agent and has shown satisfactory results. This study aimed to obtain the pharmacokinetic profiles, tissue distribution and plasma protein binding of C2 in Wistar Rats. Additionally, an HPLC method was develop...

The aim of this study was to investigate the presence of pharmaceutically relevant drug transporters in frog intestine which has been proposed as model for intestinal permeability screening assays of passively absorbed drugs in humans [Trapani, G., Franco, M., Trapani, A., Lopedota, A., Latrofa, A., Gallucci, E., Micelli, S., Liso, G., 2004. Frog intestinal sac: a new in vitro method for the as...

The sodium/iodide symporter (NIS) has been identified as an attractive target for cancer therapy. The efficacy of 131I-iodide for NIS-expressing tumor therapy may be limited by a combination of poor cellular retention and unfavorable physical characteristics (long physical half-life and low linear-energy-transfer [LET] radiative emissions). On the other hand, 211At-astatide is also transported ...

The fate of small doses of isotopically labeled isologous hemoglobin was studied in the rat. When haptoglobin depleted animals were given 2.0 mg of (59)Fe hemoglobin intravenously, nearly half was trapped by the kidneys. Kidney (59)Fe activity disappeared slowly over several weeks. Whatever iron was lost from the kidneys was largely reutilized. In contrast, the porphyrin of hemoglobin absorbed ...

LLE Review, Volume 147 150 Introduction High concentrations of tritium develop on stainless-steel (SS) surfaces exposed to a tritium atmosphere.1 These high concentrations are attributed to tritium dissolution within the adsorbed water layers present on all metal surfaces.1–4 Tritium dissolved within these layers contributes $20% to the total inventory absorbed by SS.1 Additionally, these water...

For a dietary amino acid to be retained in tissue protein in an animal, the amino acid needs to be ingested by the animal and absorbed from the intestinal tract. While the absorption of amino acids is a concept that can easily be defined, it is difficult to measure. Instead, the digestibility of amino acids is measured. Digestibility is defined as the difference between the amount of a certain ...

A sensitive immunoassay procedure for the detection of the thrombopoietic-stimulating factor (TSF) has been developed. This procedure Is similar to the hemagglutination-inhibition (HAl) technique that is available for erythropoietin. For the production of TSF, sheep were made thrombocytopenic by the Injection of antiplatelet serum. TSF from sheep sera was partially purified by column chromatogr...

The intestinal transport of lamivudine, a nucleotide reverse transcriptase inhibitor, was investigated using the single pass intestinal perfusion technique in male Wistar rats. Single pass intestinal perfusion was performed in small intestine at a flow rate of 0.20 ml/min. Lamivudine exhibits a high intestinal permeability over the length of the small intestine indicative of compounds that are ...

A Monte Carlo model of radiative transfer in multi-phase dusty media is applied to the situation of stars and clumpy dust in a sphere or a disk. The distribution of escaping and absorbed photons are shown for various filling factors and densities. Analytical methods of approximating the escaping fraction of radiation, based on the Mega-Grains approach [4], are discussed. Comparison with the Mon...

A sensitive immunoassay procedure for the detection of the thrombopoietic-stimulating factor (TSF) has been developed. This procedure Is similar to the hemagglutination-inhibition (HAl) technique that is available for erythropoietin. For the production of TSF, sheep were made thrombocytopenic by the Injection of antiplatelet serum. TSF from sheep sera was partially purified by column chromatogr...