We previously reported that MK-801 (dizocilpine), an antagonist of N-methyl-D-aspartate (NMDA)-type glutamate receptors, increased meal size and duration in rats. MK-801 did not increase sham feeding or attenuate reduction of sham feeding by intraintestinal nutrient infusions. These results suggested that the MK-801-induced increase in meal size did not depend on antagonism of postgastric satie...

Little is known of the temporal and quantitative relationships between emptying of the stomach and of the gall bladder in patients with duodenal ulcer before and after vagotomy. A non-invasive double isotope technique was used to investigate these relationships in 27 patients with a duodenal ulcer, before and after operation-truncal vagotomy and pyloroplasty (TV + P; n = 15) and highly selectiv...

Teff, Karen L., Abass Alavi, Jergin Chen, Michael Pourdehnad, and Raymond R. Townsend. Muscarinic blockade inhibits gastric emptying of mixed-nutrient meal: effects of weight and gender. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R707–R714, 1999.—We compared the vagal contribution to gastric emptying in lean and obese subjects by monitoring gastric emptying of a meal during...

Subacute ruminal acidosis can result in increased flow of fermentable substrates to the hindgut, which can negatively affect animal health and productivity. However, animal responses to increased hindgut fermentation independent of subacute ruminal acidosis have rarely been evaluated. This study determined the impact of abomasal dosage of a fermentable carbohydrate on animal performance and blo...

Leptin regulates energy homeostasis and body weight by balancing energy intake and expenditure. It was recently reported that leptin, released into the gut lumen during the cephalic phase of gastric secretion, is capable of initiating intestinal nutrient absorption. Vagal afferent neurons also express receptors for both CCK and leptin, which are believed to interact in controlling food intake. ...

Several studies have shown that fluids delivered to the stomach tend to empty more rapidly than when ingested by mouth. To better characterize the "delivery route effect" for corn oil, rats received intragastric or intraoral infusions matched for concentration and for the rate and duration of stimulus delivery. We showed, first, that more than twice as much oil emptied by the end of 12-min intr...

Milk replacers (MR) formulated to contain more lactose than whole milk could potentially reduce insulin sensitivity in dairy calves. This study evaluated how partially replacing MR with fat on a weight/weight basis affects glucose–insulin kinetics neonatal calves fed high quantities of MR. Thirty-four Holstein bull were blocked by dam parity (1.6 ± 0.3) and randomly assigned 1 2 treatments (n =...

In order to estimate the availability of ruminally-protected Lys (RPLys) and Met (RPMet), quantitative changes of free Lys and Met in the total abomasal outflow and feces were determined in three Holstein heifers with a T-shaped duodenal cannula. RPLys was prepared by coating Lys with fat and RPMet with a pH-sensitive polymer. RPLys and RPMet containing 30 g of each amino acid were supplied tog...

To evaluate the serum concentrations of haptoglobin (Hp) and serum amyloid A (SAA) in water buffaloes with abomasal ulcers, the abomasums of 100 randomly selected water buffaloes were examined after slaughter. Type I abomasal ulcers were found in 56 out of 100 buffaloes. Serum concentrations of Hp and SAA were measured. There was no significant difference between affected and non-affected buffa...

Objective: The cows that don’t have access to sufficient energy in their ration can get sickness. Milk production has a high priority in metabolism of dairy cows so lactating cows are more prone to get sick This can ruin all the benefits of higher milk yield because of the higher prevalence of the disorders. Methods: Data for this research had gathered from a herd with 1600 Holstein cattle in E...