SUMMARY: BACKGROUND: The gene locus for the ABO blood group system encodes a glycosyltransferase. Alterations in the DNA sequence are associated with the blood groups and the expression levels of antigens on red blood cells. A number of ABO alleles have been described as the molecular basis of weak A or B antigens. PATIENTS AND METHODS: Here, we describe a novel variant B allele in a blood dono...

BACKGROUND Data on frequency distribution of ABO-Rh blood groups in cardiac syndrome X (CSX) patients are not available. We aimed to investigate the distribution of ABO-Rh blood groups in these patients. MATERIALS AND METHODS A total of 247 CSX patients' records were reviewed in a cross-sectional study from 2006 to 2010. One hundred forty six patients (59.1%) were female, and the mean patient...

OBJECTIVE ABO blood group and secretor status is valuable in relation to some diseases in clinical and forensic medicine. Across the globe there are geographic and racial differences in the frequency of secretors and non-secretors. Aim of this study was to evaluate the status of ABH blood group secretors and non-secretors in Karachi (Pakistan). METHODS Blood and saliva samples were randomly c...

BACKGROUND Placental Protein 13 (PP13), an early biomarker of preeclampsia, is a placenta-specific galectin that binds beta-galactosides, building-blocks of ABO blood-group antigens, possibly affecting its bioavailability in blood. METHODS AND FINDINGS We studied PP13-binding to erythrocytes, maternal blood-group effect on serum PP13 and its performance as a predictor of preeclampsia and intr...

Venous thromboembolism (VTE) is a major health problem that results in a significant burden on hospitals and patients. VTE screening and prophylaxis protocols in trauma patients vary significantly among hospitals and providers. In addition, many patients develop VTE even in the absence of "high-risk" categories. Therefore, more research is needed to better understand and prevent VTE in these pa...

Blood group antigens of the H, ABO, Lewis, and historical “P” blood groups are defined by small carbohydrate epitopes expressed as posttranslational modifications on glycoproteins, mucins, and glycolipids. Their synthesis is complex and dependent on several distinct glycosyltransferases and interrelated biosynthetic pathways. In many cases, carbohydrate antigens share features of more than one ...

This study focuses on the association between the ABO blood group system and the risk of gastric cancer or Helicobacter pylori infection. The data for the ABO blood group was collected from 1045 cases of gastric cancer, whereby the patient underwent a gastrectomy in Ruijin Hospital, Shanghai. The information on the ABO blood group from 53,026 healthy blood donors was enrolled as control. We sea...

Disha Arora*, Ankit Kaushik, D.S. Rawat, A K Mandal Department of Pathology, Vardhaman Mahavir Medical College and Safdarjung Hospital, New Delhi, India Background: ABO blood group shows marked geographical and racial variation. The study of regional ABO phenotype is extremely important for understanding the regional demand of rare blood groups and to tide over the massive demands in case of na...