Experiments reported in the accompanying paper (1) showed that an abnormally high percentage of red cells from patients with acanthocytosis hemolyze when incubated at 370 or 40 C for 48 hours. This abnormal lysis was inhibited by heparin, supplementary glucose, and additions of normal serum. This report partially identifies the components of normal serum that inhibit such autohemolysis and the ...

Two hereditary syndromes characterized by the association of retinal changes and erythrocytic anomalies have been described: (1) Retinopathy complicating haemoglobin anomalies, thalassaemia (Rudd, Evans, and Peeney, 1953), or sickle-cell anaemia (Lieb, Geeraets, and Guerry, 1959); (2) Atypical retinitis pigmentosa with thorny erythrocytes (acanthocytosis: Bassen and Kornzweig, 1950; Kornzweig a...

A 2006 National Cancer Institute workshop on chromosomal translocations brought together laboratory, clinical, and population scientists to cross-fertilize and catalyze research on this important disease process. The deliberations revealed significant contrasts between two types of translocations that result in either deregulated expression of oncogenes or formation of novel fusion genes. The c...