نتایج جستجو برای: abc transporters

تعداد نتایج: 35243  

2011
N. S. Wind I. Holen

The development of multidrug resistance (MDR) and subsequent relapse on therapy is a widespread problem in breast cancer, but our understanding of the underlying molecular mechanisms is incomplete. Numerous studies have aimed to establish the role of drug transporter pumps in MDR and to link their expression to response to chemotherapy. The ATP-binding cassette (ABC) transporters are central to...

Journal: :Research in Microbiology 2019

Journal: :Journal of Korean Society for Clinical Pharmacology and Therapeutics 2003

Journal: :International Journal of Molecular Sciences 2021

2017
Johannes T.-H. Yeh Kwangho Nam Joshua T.-H. Yeh Norbert Perrimon

The absorption, distribution, metabolism and excretion (ADME) of metabolites and toxic organic solutes are orchestrated by the ATP-binding cassette (ABC) transporters and the organic solute carrier family (SLC) proteins. A large number of ABC and SLC transpoters exist; however, only a small number have been well characterized. To facilitate the analysis of these transporters, which is important...

Journal: :Frontiers in bioscience : a journal and virtual library 2003
Erin E Fetsch Amy L Davidson

The maltose transport complex of E.coli is one of the most well-characterized members of the ATP-Binding Cassette (ABC) protein superfamily. ABC proteins represent the largest superfamily of transmembrane proteins in prokaryotes and eukaryotes, performing diverse functions from ion transport by the cystic fibrosis transmembrane regulator to multiple drug efflux by the P-glycoprotein transporter...

2014
J. Joe Hull Kendrick Chaney Scott M. Geib Jeffrey A. Fabrick Colin S. Brent Douglas Walsh Laura Corley Lavine

ATP-binding cassette (ABC) transporters are a large superfamily of proteins that mediate diverse physiological functions by coupling ATP hydrolysis with substrate transport across lipid membranes. In insects, these proteins play roles in metabolism, development, eye pigmentation, and xenobiotic clearance. While ABC transporters have been extensively studied in vertebrates, less is known concern...

Journal: :The Journal of antimicrobial chemotherapy 2010
Wouter F W Bierman George L Scheffer Antoinet Schoonderwoerd Gerrit Jansen Michiel A van Agtmael Sven A Danner Rik J Scheper

OBJECTIVES A possible mechanism for HIV therapy failure is the efflux of HIV drugs from viral target cells or certain body compartments by ATP-binding cassette (ABC) transporters, allowing ongoing viral replication. Here, we investigated the interaction between protease inhibitors (PIs) and ABC transporters. METHODS To explore the potential blocking capacity of PIs, we exposed cells overexpre...

Journal: :Molecular microbiology 2001
A H Hosie D Allaway M A Jones D L Walshaw A W Johnston P S Poole

The ATP-binding cassette (ABC) transporter superfamily is one of the most widespread of all gene families and currently has in excess of 1100 members in organisms ranging from the Archaea to manQ1. The movement of the diverse solutes of ABC transporters has been accepted as being strictly unidirectional, with recent models indicating that they are irreversible. However, contrary to this paradig...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2013
Elena Vigonsky Elena Ovcharenko Oded Lewinson

In all kingdoms of life, ATP Binding Cassette (ABC) transporters participate in many physiological and pathological processes. Despite the diversity of their functions, they have been considered to operate by a largely conserved mechanism. One deviant is the vitamin B12 transporter BtuCD that has been shown to operate by a distinct mechanism. However, it is unknown if this deviation is an exoti...

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