نتایج جستجو برای: ab5
تعداد نتایج: 119 فیلتر نتایج به سال:
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We found that, in murine podocytes, expression of monocyte chemoattractant protein 1 (MCP-1) in response to TNF-alpha was suppressed by indomethacin but not by ibuprofen. This anti-inflammatory potential was correlated with induction of 78-kDa glucose-regulated protein (GRP78), a marker of unfolded protein response (UPR). Indomethacin, but not ibuprofen, also triggered expression of CHOP, anoth...
بیماریهای اسهالی یکی از مهمترین معضلات بهداشت جهانی، در تمامی ردههای سنی مطرح میباشند. از میان عوامل ایجاد کننده این بیماریها می-توان به Enterohemorrhagic Escherichia coli (EHEC) وVibrio cholerae اشاره کرد. در گروه EHEC سروتایپ O157:H7، شایعترین عامل ایجاد اسهال، از طریق سم STX2 ایجاد بیماری میکند. در ویبریوکلرا نیز توکسین CTX منجر به بروز بیماری میگردد. هر دوی این سموم دارای ساختار AB5...
امروزه باتریهای لیتیومی و نیکل- هیدرید فلزی به دلیل ظرفیت ذخیرهسازی بالاترِ انرژی و عدم بهکارگیری فلزات سنگین و آلاینده محیطزیست، بسیار مورد توجهاند. در باتریهای نیکل- هیدرید فلزی، آلیاژ جاذب هیدروژن در الکترودِ منفی با هیدرولیز آب به هیدرید فلز تبدیل میگردد. در پژوهشِ حاضر آلیاژ MmNi3.55Co0.75Mn0.4Al0.3 حاوی میشمتالِ غنی از سریم، با استفاده از روش قوس الکتریکی تحت خلاء سنتز شد. در ادامه، ...
Pertussis-like toxins are secreted by several bacterial pathogens during infection. They belong to the AB5 virulence factors, which bind to glycans on host cell membranes for internalization. Host cell recognition and internalization are mediated by toxin B subunits sharing a unique pentameric ring-like assembly. Although the role of pertussis toxin in whooping cough is well-established, pertus...
Natural and synthetic polyvalent ligands can act as inhibitors of biological processes or as effectors of signal-transduction pathways. 2] In the case of carbohydrate–lectin interactions, polyvalency is of particular importance because individual carbohydrate epitopes are usually bound with only weak affinity and often broad specificity. The potency of a polyvalent inhibitor depends on the spat...
To improve the quality of manufactured products, it is necessary to all technologicalprocesses, which requires increasing accuracy entire measuring path as a whole.For this carefully analyze systematic, random and fluctuating errors in measurementchannel take measures reduce them. Digital filtering or averaging intermediatemeasurements (observations) according certain rules radical means improv...
BACKGROUND Because agents which inhibit the receptor binding of cholera toxin constitute possible lead compounds for the structure-based design of anti-cholera drugs, detailed investigation of the toxin's receptor-binding site is of key importance. The substitution Gly-->Asp at residue 33 of the cholera toxin B subunit (CTB) has been reported to abolish receptor-binding ability. The substitutio...
Vibrio cholerae produces cholera toxin (CT), an AB5 protein toxin that is primarily responsible for the profuse watery diarrhea of cholera. CT is secreted into the extracellular milieu, but the toxin attacks its Gsα target within the cytosol of a host cell. Thus, CT must cross a cellular membrane barrier in order to function. This event only occurs after the toxin travels by retrograde vesicula...
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