The biodistribution and removal from plasma (measured as fractional clearance rate, FCR, per hour) of native and oxidatively modified 99mtechnetium-labeled beta-very low density lipoprotein (99mTc-beta-VLDL) were investigated in hypercholesterolemic (HC) and control (C) three-month old New Zealand rabbits. The intracellular accumulation of beta-VLDL labeled with 99mTc was studied in vitro in TH...

UNLABELLED This study was designed to compare the tracer kinetics between 99mTc-sestamibi and 99mTc-tetrofosmin in a heterogeneous group of 24 patients admitted for routine perfusion imaging. METHODS Twelve patients were studied with 99mTc-tetrofosmin and 12 with 99mTc-sestamibi. In each group, six patients had a low likelihood for coronary artery disease, and six patients had angiographicall...

99mTc-[bis (dimethoxypropylphosphinoethyl)-ethoxyethylamine (PNP5)]-[bis (N-ethoxyethyl)-dithiocarbamato (DBODC)] nitride (N-PNP5-DBODC or N-DBODC5) is a new monocationic myocardial perfusion tracer. We sought to compare the myocardial uptake and clearance kinetics and organ biodistribution of 99mTc-N-DBODC5 with 99mTc-sestamibi and 99mTc-tetrofosmin. Methods: Seventy-five anesthetized Sprague–...

Secure determination of the binding of 99mTc-radiopharmaceuticals to plasma (P) and blood cell (BC) constituents can help to understand the biodistribution of radiophamaceuticals. The reported precipitation studies of blood with radiopharmaceuticals have shown that the results can not be easily compared between studies. We decided to determine the "gold standard" concentration of trichloroaceti...

In the title molecule, C(9)H(3)Cl(3)O(3), there are three short interactions involving the benzene H atoms and the chloro-formyl Cl atoms. In the crystal, mol-ecules stack along the a axis with no significant non-bonded inter-actions.

Thiamazole inhibits the thyroid hormone synthesis and does not inactivate existing thyroxine triiodothyronine that circulate in blood. In this paper electrochemical behavior was monitored by cyclic voltammetry on glassy carbon (GC) electrode absence presence of sodium pertechnetate (99mTc). The influence different concentrations without radiopharmaceutical 99mTc, effect number scan cycles, 99mT...

130 years after Mond discovered the first homoleptic carbonyl complex Ni(CO)4, we report on a [Ni(CO)4].+ salt as synthesis of any nickel cation in condensed phase. It was prepared by oxidation metal with synergistic oxidant Ag[F{Al(ORF)3}2]/0.5 I2 (RF=C(CF3)3) CO atmosphere. This D2d-symmetric metalloradical represents last missing entry among structurally characterized cations Groups 6 to 11....

Rhenium(I) N-heterocyclic carbene (NHC) complexes of the type fac-[Re(CO)3(NHC)L] with either azide or triazolate ancillary ligands L and pyridyl or pyrimidyl substituted imidazolyl units have been prepared and structurally characterised, and their photophysical and photochemical properties studied. All of the complexes exhibit phosphorescent emission from triplet metal-to-ligand (MCLT) excited...

introduction: the use of radiopharmaceuticals is a powerful tool in the management of patients with infectious or inflammatory diseases in nuclear medicine. in this study ofloxacin as a second-generation fluoroquinolone is used to design a desired infection imaging agent after labeling with 99mtc via direct labeling. methods: ofloxacin was radiolabeled with 99mtc using different concentrations ...