We applied a renal blood flow (RBF) quantification technique to pediatric data, which depends minimally on bolus shape, uses a conventional radiopharmaceutical 99mTc-DTPA, and generates a value for RBF as a percentage of cardiac output (RBF/CO). Mean RBF was 16.9% (+/- 4.8) for normal transplants, 13.1% (+/- 2.9) for transplants undergoing mild-to-moderate chronic rejection, 7.9% (+/- 1.3) for ...

This case report involves a 45-y-old woman after cadaveric renal transplantation. The initial renal scan on the first postsurgical day showed normal findings. Subsequently, on the sixth postsurgical day, the patient had decreased urine output; 99mTc-diethylenetriaminepentaacetic acid renal scanning was performed again and did not show definite scintigraphic evidence of a urine leak. The patient...

The fraction of injected activity that was excreted through the breast milk of nursing mothers at different times after the injection of various radiopharmaceuticals has been measured in 21 patients. For 99mTc-labeled radiopharmaceuticals the total excreted fraction was 10% for pertechnetate and 1.5-3% for MAA, plasmin, diethylenetriaminepentaacetic acid (DTPA), and methylene diphosphonate (MDP...

Unexpected iliac uptake of 99mTc-DTPA was noted in a 10-year old female referred for evaluation of renal function prior to receiving chemotherapy for relapsed acute lymphocytic leukemia. This scan finding corresponded to the site of a bone marrow biopsy performed five days earlier. X-ray of the area revealed no abnormality. It is assumed that the extrarenal uptake was due to increased vasculari...

BACKGROUND Increased pulmonary epithelial permeability evaluated by the rate of clearance from lung to blood of the radioaerosol solute technetium-99m labelled diethylenetriamine pentaacetate (99mTc-DTPA) has been reported in smokers and in workers exposed to silica dust. A study was carried out to determine whether there are additive effects of cigarette smoke and exposure to silica dust on cl...

UNLABELLED The constant-volume urinary bladder model in the standard MIRD Pamphlet No. 5 (Revised) phantom has recognized limitations. Various investigators have developed detailed models incorporating more physiologically realistic features, such as expanding bladder contents and residual volume, and variable urinary input rate, initial volume and first void time. We have reviewed these publis...

Wagner, Elizabeth M., and W. Michael Foster. Bronchial edema alters 99mTc-DTPA clearance from the airway surface in sheep. J Appl Physiol 91: 2567–2573, 2001.— Airway wall edema, prominent in inflammatory airways disease, may alter barrier properties at the airway airliquid interface such that normal absorption of soluble substances into the airway circulation is altered. We studied the effects...

The optimal management of children with antenatally diagnosed unilateral hydronephrotic kidneys is unclear. We have monitored renal function and drainage using 99mTc-DTPA renography in 77 children with such kidneys presenting at 1-14 mo of age with the aims of throwing light on the natural history of the condition and evaluating the response of the kidney to pyeloplasty. Since management was in...

Postischemic acute renal failure (ARF) induced by cardiac surgery is commonly prolonged and may be irreversible. To examine whether persistence of postischemic, tubular cell injury accounts for delayed recovery from ARF, we studied 10 patients developing protracted (36 +/- 4 d) ARF after cardiac surgery. The differential clearance and excretion dynamics of probe solutes of graded size were dete...