Radiopharmaceuticals are employed in patient diagnostics and disease treatments. Concerning the diagnosis aspect, technetium-99m (99mTc) is utilized to label radiopharmaceuticals for single photon computed emission tomography (SPECT) due to its physical and chemical characteristics. 99mTc fixation on pharmaceuticals depends on a reducing agent, stannous chloride (SnCl(2)) being the most widely-...

Calciphylaxis is a rare devastating medical condition commonly associated with end-stage renal disease and characterized by extensive microvascular calcifications. We describe a case of calciphylaxis presenting on Tc-99m MDP bone scan imaging with asymmetric radiotracer uptake within the lower extremities corresponding to extensive soft tissue calcifications on Computed tomography. Familiarity ...

Introduction: 99mTc-Methylene diphosphonate (99mTc-MDP) three phase bone scintigraphy (TPS) is beneficial to evaluate the success of femoral head revascularization using novel distraction osteogenesis techniques with bone muscle pedicle grafts. This pilot study was undertaken to evaluate the feasibility and utility of 99mTc-MDP three phase bone ...

Radionuclide 99mTc-MDP planar bone scan is the most commonly performed nuclear medicine procedure and may aid diagnosis of benign and malignant bone pathologies. 99mTc-MDP is injected intravenously and subsequently taken up by osteoblasts and incorporated into the bone matrix. In the process it acts as a marker for new bone formation, bone turnover and local vascularity. The high sensitivity of...

A 64-year-old woman, with amyloid related kidney failure (On renal dialysis) had a bone scan because of pain in the right upper femur. The 99m Tc-MDP images revealed marked hepatic uptake. In addition, there was right proximal femoral concentration of radiotracer, which corresponded to a fracture site. As an added finding, the same femor demonstrated circumferential uptake at the lower po...

An enostosis or bone island is a benign bony lesion that is almost diagnosed based on clinical and radiologic defining characteristics. One of the known diagnostic procedures in the evaluation of enostosis is bone scintigraphy. Generally, we don’t expect to see increased uptake by enostosis in the bone scan. Herein we present a 52-year-old lady who was suffering from chronic low back pain that ...

OBJECTIVE The diagnosis of active inflammation in ankylosing spondylitis (AS) is crucial for treatment to delay possible persistent deformities. There are no specific laboratory tests and imaging methods to clarify the active disease. We evaluated the value of Tc-99m human immunoglobulin (HIG) scintigraphy in detection of active inflammation. MATERIAL AND METHODS Twenty-nine patients were inc...

BACKGROUND Phytoestrogens are plant-derived natural molecules having some bone forming and bone substituting effects. In the present study, the role of phytoestrogens on bone healing was investigated in a rabbit fracture model. METHODS Twenty-two New Zealand white rabbits with right tibia fracture were divided into two groups randomly. The plant derived extract of Vitex agnus-castus L. (Verbe...

Fig. 2 A 41-year-old man who suffered from pain in several joints for more than 10 years was referred for a bone scintigraphy. The patient was treated with non-steroidal anti-inflammatory drugs, but this treatment regimen did not result in a reduction of symptoms. Upon completion of the physical examination, no remarkable findings were noted. All routine laboratory tests were normal. The images...