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RWMODELII simulates the Rescorla-Wagnermodel oj Pavlovian conditioning, lt is written in Delphi and runs under Windows 3,1 and Windows 95, The program was designed[or novice and expert users and ?an beemr:loyed in teaching as well as in research. It is user jnendly and require~ a minimal level ofcomputer literacy but is sujjiciently flexible to permit a wide range of simulations. It allows the ...

95 THE CANADIAN HIGHWAY NETwork consists mainly of two-lane highways where passing slower cars requires traveling in the lane assigned to the opposite traffic. Therefore, studying the mechanism of the passing maneuver is important for maintaining traffic safety, as well enhancing the highway’s level of service. Models for passing maneuvers are available in the design guides1,2 while different v...

To address the unsolved question of PSD-95 function I used short hairpin RNA (shRNA) to knock-down protein expression. shRNA mediated knock-down of protein expression is one of the established methods exploiting the naturally occurring expression control mechanism known as RNA interference (RNAi). Cells express shRNAs that are complementary to the mRNA they control. The shRNAs are processed and...

We evaluated the efficacy, potency, and selectivity of the three most commonly used adenylate cyclase (AC) inhibitors in a battery of cell lines constructed to study signaling via three discrete cAMP sensors identified in neuroendocrine cells. SQ22,536 [9-(tetrahydrofuryl)-adenine] and 29,59-dideoxyadenosine (ddAd) are effective and potent AC inhibitors in HEK293 cells expressing a cAMP respons...