OBJECTIVE To identify the optimal pulse sequence for ferumoxides-enhanced magnetic resonance (MR) imaging in the detection of hepatocelluar carcinomas (HCCs). MATERIALS AND METHODS Sixteen patients with 25 HCCs underwent MR imaging following intravenous infusion of ferumoxides. All MR studies were performed on a 1.5-T MR system, using a phased-array coil. Ferumoxides (Feridex IV) at a dose of...

Flavocytochrome P450 BM3 is a member of the diflavin reductase enzyme family. Members include cytochrome P450 reductase, nitric-oxide synthase, methionine synthase reductase, and novel oxidoreductase 1. These enzymes show a strong preference for NADPH over NADH as reducing coenzyme. An aromatic residue stacks over the FAD isoalloxazine ring in each enzyme, and in some cases it is important in c...

Despite the availability of numerous antiepileptic drugs (AEDs), some epilepsies remain resistant to treatment. We compared utilization and costs in patients with uncontrolled epilepsy to those with stable epilepsy. Claims data (2007-2009) were used to identify adults with epilepsy requiring additional AED therapy (having uncontrolled epilepsy) and those not requiring additional AED therapy (ha...

The Dulmage–Mendelsohn decomposition (or the DM-decomposition) gives a unique partition of the vertex set of a bipartite graph reflecting the structure of all the maximum matchings therein. A bipartite graph is said to be DM-irreducible if its DM-decomposition consists of a single component. For connected bipartite graphs, this is equivalent to the condition that every edge is contained in some...

This paper argues that Old Japanese (eighth century) had split alignment, with nominative-accusative alignment in main clauses and active alignment in nominalized clauses. The main arguments for active alignment in nominalized clause come from ga-marking of active subjects and the distribution oftwo verbal prefixes: /-for active predicates and safor inactive predicates (cf. Yanagida, In: Hasega...

BACKGROUND The effect of care setting on value of colon cancer care is unknown. METHODS A Surveillance, Epidemiology, and End Results (SEER)-Medicare cohort study of 6544 patients aged ≥ 66 years with stage IV colon cancer (based on the American Joint Committee on Cancer staging system) who were diagnosed between 1996 and 2005 was performed. All patients were followed through December 31, 200...

OF HIGH DIMENSIONAL WAVE EQUATION Vladimir Georgiev1 and Hiroyuki Takamura2 and Zhou Yi3 1Dipartimento di Matemati a "L.Tonelli, Università di Pisa, Via F. Buonarroti 2, 56127 Pisa, Italy. e-mail: georgiev dm.unipi.it 2Institute of Mathemati s, University of Tsukuba Tsukuba Ibaraki 305-8571, Japan. e-mail: takamura math.tsukuba.a .jp 3Institute of Mathemati s, Fudan University Shanghai 200433, ...

Epidemiologic studies investigating the differences in respiratory outcomes between asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS) and chronic obstructive pulmonary disease (COPD) in an Asian population are lacking.We conducted a population-based cohort study to compare the incidence of acute respiratory events between ACOS and COPD cohorts in Taiwan. This study investigat...