Prior work presented by us identified, in both pre-clinical models and a phase 2 clinical trial of sapanisertib (NCT02417701), that lung squamous cell carcinomas (LUSC) harboring NRF2 activating mutations are sensitive to treatment with the TORC1/2 inhibitor sapanisertib. Further preclinical data suggests suppression glycolysis is potentiated targeting glutaminolysis helps fuel Krebs cycle, whi...

The effectiveness of chemotherapy targeted to somatostatin (SST) receptors based on cytotoxic SST analogue AN-238, consisting of 2-pyrrolinodoxorubicin (AN-201) linked to SST carrier octapeptide, was investigated in human renal cell carcinomas (RCCs). SST receptors, which showed high-affinity binding for AN-238, were found in the SW-839 RCC line with sst2A subtype and in the 786-0 RCC line, whi...

The present study was undertaken to investigate whether the unusual accumulation of glycogen and its relationship to the process of cell growth, already shown in human colon tumor cell lines, also applied to malignant cell lines originating from other tissues. The glycogen content was measured during the exponential phase of growth in culture of 58 human tumor cell lines, most of them originati...

The fluorescence of photosystem I (PSI) trimers in proximity to bimetallic plasmonic nanostructures have been explored by single-molecule spectroscopy (SMS) at cryogenic temperature (1.6 K). PSI serves as a model for biological multichromophore-coupled systems with high potential for biotechnological applications. Plasmonic nanostructures are fabricated by thermal annealing of thin metallic fil...

1 Université Paris Descartes, Faculté de Médecine, INSERM (U-570), Paris, France. 2 Institut Cochin, Université Paris Descartes, CNRS (UMR 8104), Paris, France. 3 INSERM, U567, Paris, France. 4 INSERM UMR-S 839, Université Pierre et Marie Curie-Paris6, Institut du Fer à Moulin, Paris, France. 5 AP-HP, Hôpital Necker-Enfants Malades, Paris, F-75015, France. 6 Weill Cornell Medical College, New Y...

839 All Rights Reserved © 2013 IJARCET Abstract Wireless hosts are usually powered by batteries which provide a limited amount of energy. Therefore, techniques to reduce energy consumption are of interest. One way to conserve energy is to use power saving mechanisms. Power saving mechanisms allow a node to enter a doze state by powering off its wireless network interface when deemed reasonable....

Social exchange, intimacy and relatedness are a basic human need. Not surprisingly, there is a number of means to mediate relatedness over a distance, such as the telephone, Skype or Facebook. However, each of these imposes a particular way of communication, constrained by the employed technology rather than deliberately shaped by the designer. In line with an experience-driven approach to tech...

Previous studies have demonstrated that the benzo[c]phenanthridine alkaloid chelerythrine chloride (CC) has inhibitory effects on various tumors. However, the anticancer activity of CC and its underlying mechanisms have not been elucidated in renal cancer cells. The present study examined the effects of CC on growth inhibition and apoptosis of renal cancer cells in vitro and in vivo. Flow cytom...