BACKGROUND Identification of markers for prediction of the clinical course of diabetic nephropathy remains a major challenge in disease management. We established a proteomics approach for identification of diabetic nephropathy-related biomarkers in urine. METHODS We used SELDI-TOF mass spectrometry and SAX2 protein arrays to compare protein profiles from urine of 4 defined patient groups. Sa...

BACKGROUND AND PURPOSE Stent-assisted coiling has expanded the treatment of intracranial aneurysms, but the rates of procedure-related neurological complications and the incidence of angiographic aneurysm recurrence of this novel treatment are not yet well known. We present our experience with stent-assisted coiling with special emphasis on procedure-related neurological complications and incid...

OBJECTIVE Polymorphisms located at microRNA (miRNA) binding sites may interfere with the miRNA/mRNA interaction. The objective of this study was to identify the association between a single nucleotide polymorphism (774 T>C) in 3'-untranslated region (3'-UTR) of Epithelial Growth Factor Receptor (EGFR) and development of pulmonary hypertension (PH) in chronic obstructive pulmonary disease (COPD)...

Diabetes Mellitus and chronic hyperglycemia are associated with many complications including delayed wound healing diabetic foot ulcers. Mechanisms behind this failure remain poorly understood but may include differential expression of two molecules, tumor necrosis factor stimulated gene 6 (TSG-6) thrombospondin 1 (TSP-1). These proteins, which interact each other, play important roles in displ...

ADAPTATION TO VISUOMOTOR ROTATION THROUGH INTERACTION BETWEEN 2 POSTERIOR PARIETAL AND MOTOR CORTICAL AREAS 3 4 Hirokazu TANAKA 1,3 , Terrence J. SEJNOWSKI, John W. KRAKAUER 2 5 6 1 Howard Hughes Medical Institute, Computational Neurobiology Laboratory, The Salk Institute for 7 Biological Studies, La Jolla, CA 92037 8 2 Motor Performance Laboratory, Department of Neurology, Columbia University ...

Protease activity of actinomycetes isolated from various soil types of Georgia has been studied. Protease activity strains have been identified among mesophilic and extremophilic actinomycetes. Some strains of mesophilic, alkaliphilic and halophilic actinomycetes are characterized by alkaline protease activity. Their pH optimum for enzyme activity is 10-11. Strains of mesophilic actinomycetes: ...