Cyanobacteria are able to produce a wide range of secondary metabolites, including toxins and protease inhibitors, with diverse biological activities. Microginins are small linear peptides biosynthesized by cyanobacteria species that act against proteases. The aim of this study was to isolate and identify microginins produced by the LTPNA08 strain of Microcystis aeruginosa, as well as to verify...

W1282X is a common nonsense mutation among cystic fibrosis patients that results in the production of a truncated Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) channel. Here we show that the channel activity of the W1282X-CFTR polypeptide is exceptionally low in excised membrane patches at normally saturating doses of ATP and PKA (single channel open probability (PO) < 0.01). Howev...

Abstract Aim Right iliac fossa (RIF) pain is a common acute surgical presentation, with appendicitis being the main differential diagnosis. In women of childbearing age, abdominal and pelvic ultrasounds (USS) are often imaging modality choice can be particularly useful when diagnosis unclear. We aimed to determine diagnostic value USS in patients presenting RIF pain. Method A single centre retr...

∗ School of Electrical Engineering and Computer Science, Ohio University, Athens, OH 45701, email: [email protected], [email protected], tel: (740)593-1580, fax: (740)593-0007. Abstract − This paper presents a novel P-code generator design strategy and direct GPS P-code acquisition technique. This method not only helps software simulation and simplifies FPGA hardware desi...

The most common mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene leads to deletion of the phenylalanine at position 508 (ΔF508) in the CFTR protein and causes multiple folding and functional defects. Contrary to large-scale efforts by industry and academia, no significant therapeutic benefit has been achieved with a single "corrector". Therefore, investigations co...

BACKGROUND Dermatologists besides providing service to patients in the outdoors, also play a vital role in the care of inpatients admitted to dermatology unit and other departments. AIMS The aim of this study was to evaluate the pattern of referrals sent to the dermatology department by other departments. MATERIALS AND METHODS The study included all inpatients referred to dermatology depart...

Barry W. Boehm, Ph.D. Christopher M. Abts, M.S. Elizabeth K. Bailey, Ph.D. Center for Software Engineering Center for Software Engineering University of Southern California University of Southern California Software Metrics, Inc. 941 W. 37 Place, SAL 328 941 W. 37 Place, SAL 328 4345 High Ridge Road Los Angeles, CA 90089-0781 Los Angeles, CA 90089-0781 Haymarket, Virginia 20169 +1-213-740-5703 ...

1Endocrine and Metabolism Research Centre, Doctor Shariati Hospital, Tehran University, Tehran, Islamic Republic of Iran. 2Health Research and Education Unit, Healthcare Organization, National Iranian Oil Corporation, Tehran, Islamic Republic of Iran. Received: 30/07/02; accepted: 27/03/03 ABSTRACT To estimate the direct cost of coronary heart disease (CHD) to the Iranian oil industry, we calcu...

[This corrects the article on p. 770 in vol. 12, PMID: 28616034.].