A series of new coumarin-derived carboxylate ligands and their silver(I) complexes have been synthesized, characterized and screened for their in vitro antibacterial activity against a range of Gram-positive and Gram-negative bacteria as well as for their antifungal activity against a clinical isolate of Candida albicans. The ligands were synthesised by either acid or base hydrolysis of their c...

The total of fourteen known compounds was isolated from the fruits, leaf and stem of Fadogia homblei De Wild. (Rubiaceae) and identified as: a coumarin, 7-hydroxy-6-methoxy-2H-1benzopyran-2-one (scopoletin) 1, two flavones; 3′,4′,5,7-tetrahydroxyflavone (luteolin) 2 and quercetin-3-O-β-D-galactoside 3, four lupane triterpenoids; lupeol 4, betulinic acid 5, 3βdodecanoyllup-20(29)-en-28-al 6, lup...

ABSTRACT Coumermycin A1 was early recognized as a potentially useful antibiotic because of its very good spectrum of activity against gram-positive organisms (particularly against staphylococci), in addition to appreciable activity against a variety of gram-negative bacteria. However, in spite of its excellent in vitro activity, the insoluble character of coumermycin A1 made parenteral administ...

New coumarin derivatives, namely 7-[(5-amino-1,3,4-thiadiazol-2-yl)methoxy]-2H-chromen-2-one, 5-[(2-oxo-2H-chromen-7-yloxy)methyl]-1,3,4-thiadiazol-2(3H)-one, 2-[2-(2-oxo-2H-chromen-7-yloxy)acetyl]-N-phenylhydrazinecarbothioamide, 7-[(5-(phenylamino)-1,3,4-thiadiazol-2-yl)methoxy]-2H-chromen-2-one and 7-[(5-mercapto-4-phenyl-4H-1,2,4-triazol-3-yl)methoxy]-2H-chromen-2-one were prepared starting...

AIM To evaluate the anti-nociceptive activity of 7-methoxy coumarin isolated from ethyl acetate fraction of the alcoholic extract of Eupatorium triplinerve Vahl. MATERIALS AND METHODS The shade dried leaves of E. triplinerve were extracted with ethyl alcohol and the extract was condensed. This extract was fractionated with n-hexane, ethyl acetate, and n-butanol. The ethyl acetate fraction was...

A new geranylated coumarin, (E)-4-(1-hydroxypropyl)-5,7-dihydroxy-6-(3,7-dimethyl-2,6-octadienyl)-8-(3-methyl-1-oxobutyl)coumarin (named surangin D), was isolated from the bark of Mammea siamensis collected in Vietnam, along with four known coumarins, surangins B and C, and theraphins B and C, and seven xanthones, 1,7-dihydroxyxanthone, 7-hydroxy-1-methoxyxanthone, 1,7-dimethoxyxanthone, 1,7-di...

Submit Manuscript | http://medcraveonline.com glycosides and lactone glycosides, including protoaesigenin, barringeogenol-C, {reference 2) hippocaesculin, 6-E-glucoside7-hydroxy coumarin, and others, collectively called aescin (or occasionally escin). It also provides aesculic acid, aesculinic acid, an appreciable level of flavonoids (esculin, esculetin, rutin, kaempferol), tannins, starches, m...