نتایج جستجو برای: 7 dht
تعداد نتایج: 645481 فیلتر نتایج به سال:
Post-translational degradation of protein plays an important role in cell life. We employed chimeric molecules (dihydrotestosterone-based proteolysis-targeting chimeric molecule [DHT-PROTAC]) to facilitate androgen receptor (AR) degradation via the ubiquitin-proteasome pathway (UPP) and to investigate the role of AR in cell proliferation and viability in androgen-sensitive prostate cancer cells...
We have identified dihydroxythiophenes (DHT) as a novel series of human immunodeficiency virus type 1 (HIV-1) integrase inhibitors with broad antiviral activities against different HIV isolates in vitro. DHT were discovered in a biochemical integrase high-throughput screen searching for inhibitors of the strand transfer reaction of HIV-1 integrase. DHT are selective inhibitors of integrase that...
BACKGROUND Testosterone (T) controls male Syrian hamster sexual behavior, however, neither of T's primary metabolites, dihydrotestosterone (DHT) and estradiol (E(2)), even in highly supraphysiological doses, fully restores sexual behavior in castrated hamsters. DHT and T apparently interact with androgen receptors differentially to control male sexual behavior (MSB), but whether these two hormo...
The objective of this study was to synthesize several new pregnane derivatives and evaluate them as antiandrogens. From the commercially available 16-dehydropregnenolone acetate (7), two new steroidal compounds were synthesized: 17alpha-hydroxy-17beta-methyl-16beta-phenyl-D-homoandrosta-1,4,6-triene-3,20-dione (18) and 17alpha-acetoxy-17beta-methyl-16beta-phenyl-D-homoandrosta-1,4,6-triene-3,20...
Usenet is a popular distributed messaging and file sharing service: servers in Usenet flood articles over an overlay network to fully replicate articles across all servers. However, replication of Usenet’s full content requires that each server pay the cost of receiving (and storing) over 1 Tbyte/day. This paper presents the design and implementation of UsenetDHT, a Usenet system that allows a ...
BACKGROUND Biotransformation is an effective technique for the synthesis of libraries of bioactive compounds. Current study on microbial transformation of dihydrotestosterone (DHT) (1) was carried out to produce various functionalized metabolites. RESULTS Microbial transformation of DHT (1) by using two fungal cultures resulted in potent butyrylcholinesterase (BChE) inhibitors. Biotransformat...
introduction: it has been shown that gama-ifn is one of the major cytokines involved in lung fibrosis. it has also been demonstrated that nitric oxide (no) may exert vasodilation, edema and cytotoxicity, and it may stimulate cytokinedependent processes in the lungs. in this study, the effect of 17-beta estradiol (17-betae2) and five alpha dihydrotestosterone (5alfa-dht) on no release by tgf bet...
Liu and Chambers /3/ were the first to demonstrate collateral sprouting in the spinal cord, followed by other examples of lesioninduced sprouting in the dorsal columns/2/. The signals for sprouting in the CNS are not known, and the functional consequences of sprouting have not been addressed in most systems. Sunde and Zimmer /5/ pointed out that sprouting is not equivalent to regeneration. The ...
Intraovarian hyperandrogenism is one of the determining factors of follicular arrest in women with polycystic ovary syndrome (PCOS). Using androgenized rat models, we investigated the effects of androgens on metabolism, as well as on factors involved in follicular arrest and the reduced number of estrus cycles. The dihydrotestosterone (DHT)-treated rats had fewer estrus cycles, higher numbers o...
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