نتایج جستجو برای: 68ga
تعداد نتایج: 1443 فیلتر نتایج به سال:
PET with 68Ga from the TiO2- or SnO2- based 68Ge/68Ga generators is of increasing interest for PET imaging in nuclear medicine. In general, radionuclidic purity (68Ge vs. 68Ga activity) of the eluate of these generators varies between 0.01 and 0.001%. Liquid waste containing low amounts of 68Ge activity is produced by eluting the 68Ge/68Ga generators and residues from PET chemistry. Since clear...
گالیم-68 یکی از رادیوایزوتوپ های مهم گسیلنده پوزیترون است که در تصویر برداری pet برای تشخیص تومور و بافت سرطان در پزشکی هسته ای مورد استفاده قرار می گیرد. در این پروژه تابع برانگیختگی گالیم-68 توسط دو کد محاسباتی alice-91 وtalys-1.0 برای واکنش های هسته ای 68zn(p,n)68ga، 68zn(d,2n)68ga، 70zn(p,3n)68ga و 65cu(α,n)68ga بررسی شده است. پارامترهای تولید گالیم-68(ضخامت هدف مورد نیاز و بازده تولید گالی...
Nuclear Imaging in Patients with Differentiated Thyroid Cancer and Negative Radioactive Io-dine Scan
Background: Thyroid cancer is the most common endocrine malignancy in the world; however, these patients usually experience a high survival rate if they receive appropriate and timely treatment. Meanwhile, patients classified as having differentiated thyroid cancer with high thyroglobulin and negative iodine scan [Differentiated thyroid cancer with thyroglobulin elevation and negative iodine sc...
هدف از این پایان نامه تهیه کمپلکس 68ga-dotatoc برای تصویربرداری pet از تومورهای با گیرنده سوماتوستاتین می باشد.دراین مطالعات شرایط بهینه نشاندارسازی تعیین گردید. پایداری ترکیب نشاندار شده نیز در دمای اتاق و در سرم انسانی با دمای °c37 تا 2 ساعت بررسی گردید. نهایتا کمپلکس تهیه شده به موش صحرایی سالم تزریق شده و مطالعات توزیع زیستی کمپلکس در زمان های 15، 30، 60 و 120 دقیقه انجام پذیرفت. برای ار...
Lipophilic cationic technetium-99m-complexes are widely used for myocardial perfusion imaging (MPI). However, inherent uncertainties in the supply chain of molybdenum-99, the parent isotope required for manufacturing 99Mo/99mTc generators, intensifies the need for discovery of novel MPI agents incorporating alternative radionuclides. Recently, germanium/gallium (Ge/Ga) generators capable of pro...
GLP-1 receptors are ideal targets for preoperative imaging of benign insulinoma and for quantifying the beta cell mass. The existing clinical tracers targeting GLP-1R are all agonists with low specific activity and very high kidney uptake. In order to solve those issues we evaluated GLP-1R agonist Ex-4 and antagonist Ex(9-39) radioiodinated at Tyr40 side by side with [Nle14,Lys40(Ahx-DOTA-68Ga)...
99mTc-Macroaggregated Albumin (99mTc-MAA) has been used as a perfusion agent. This study described development of the 68Ga-MAA via commercially available kits from Pars-Isotopes Company as a 99mTc-MAA kit. 68Ge/68Ga generator was eluted with suprapure HCl (0.6 M, 6 mL) in 0.5 mL fractions. The two fractions with the highest 68GaCl3 activity were generally used for labeling purposes. After label...
Background Recently, 44Sc (T1/2 = 3.97 h, Eβ+av = 632 keV, I = 94.3 %) has emerged as an attractive radiometal candidate for PET imaging using DOTA-functionalized biomolecules. The aim of this study was to investigate the potential of using NODAGA for the coordination of 44Sc. Two pairs of DOTA/NODAGA-derivatized peptides were investigated in vitro and in vivo and the results obtained with 44Sc...
A 54-year-old woman with suspicion of neuroendocrine tumor (NET) was referred for 68Ga-DOTATATE positron emission tomography/computed tomography (CT) imaging due to clinical findings. A well-defined osteolytic lesion on the corpus of the third lumbar vertebra was evident on CT images with mild uptake of 68Ga-DOTATATE, which led to suspicion of NET metastasis. Histopathologic examination reveale...
Abstract We in this article have presented a review of the guideline recommendations on theranostic positron emission tomography-computed tomography (PET-CT) imaging which will be helpful to assist practitioners providing appropriate patient care. Multiple guidelines by different societies and medical associations provide standards for diagnosis, imaging, treatment cancer patients. They generat...
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