Acacia mearnsii De Wild. (Fabaceae) is a medicinal plant used in the treatment of microbial infections in South Africa without scientific validation of its bioactivity and toxicity. The antimicrobial activity of the crude acetone extract was evaluated by both agar diffusion and macrobroth dilution methods while its cytotoxicity effect was assessed with brine shrimp lethality assay. The study sh...

Abstract Excess platelet activation by extracellular vesicles (EVs) results in trophoblast inflammasome activation, interleukin 1? (IL-1?) preeclampsia (PE), and partial embryonic lethality. Embryonic thrombomodulin (TM) deficiency, which causes lethality hallmarked impaired proliferation, has been linked with maternal activation. We hypothesized that placental TM loss, are mechanistically to H...

The immunomodulatory activity of Cod liver oil (CLO) was evaluated by mice lethality test, carbon clearance assay, neutrophil adhesion test, cyclophosphamide-induced neutropenia, indirect haemagglutination test and effect on serum immunoglobulin levels. CLO was administered orally at a dose of 0.5 g/kg or 1 g/kg body weight. In mice lethality test, low dose of CLO (0.5 g/kg, po) produced 40% de...

Intrinsic postzygotic reproductive isolation is thought to result from the substitution of multiple harmless or beneficial genetic differences between species that are incidentally deleterious when combined in species hybrids, causing hybrid sterility or inviability. Genetic variability for hybrid sterility or inviability phenotypes is, however, rarely assessed in natural populations. Here, we ...

Certain of the cyclic cationic polypeptide antibiotics, polymyxin B, colistin, and tyrocidine, prevent the lethal effect of endotoxin for chick embryos when admixed with the toxin prior to intravenous injection. In this system, 25 ,ug of polymyxin B sulfate prevented the toxicity of 0.217 ,ug (241 LD50) of Escherichia coli endotoxin; an antibiotic-endotoxin weight ratio of 115:1. (D. Rifkind an...

An unexpected high level of acute lethality has been documented following Photofrin II-mediated photodynamic therapy (PDT) treatments which were localized to the hind leg of normal and tumor-bearing mice. Doses of PDT which induced lethality (10 mg/kg Photofrin II, 200-500 J/cm2) were in the range of doses required to obtain murine tumor cures. The percentage of lethality was proportional to th...

Vitamin A and its derivatives have recently reported to be implicated in synaptic plasticity. The possible effect of vitamin A and its precursor, ?-carotene, on seizure acquisition was tested in PTZ kindling model of epilepsy. Vitamin A and ?-carotene were tested for their ability to 1) suppress seizures (clonic and tonic) and lethality induced by PTZ in PTZ-kindled mice (anticonvulsant effect)...

the immunomodulatory activity of cod liver oil (clo) was evaluated by mice lethality test, carbon clearance assay, neutrophil adhesion test, cyclophosphamide-induced neutropenia, indirect haemagglutination test and effect on serum immunoglobulin levels. clo was administered orally at a dose of 0.5 g/kg or 1 g/kg body weight. in mice lethality test, low dose of clo (0.5 g/kg, po) produced 40% de...

A major goal in cancer medicine is to find selective drugs with reduced side effect. A pair of genes is called synthetic lethality (SL) if mutations of both genes will kill a cell while mutation of either gene alone will not. Hence, a gene in SL interactions with a cancer-specific mutated gene will be a promising drug target with anti-cancer selectivity. Wet-lab screening approach is still so c...