A series of dibenzo[b,e]ox(thi)epin-11(6H)-one O-benzoyloximes has been synthesized and structurally elucidated by means of IR, (1)H-NMR, (13)C-NMR, MS, and elemental analysis. The newly developed compounds were screened at concentrations of 200-25 μg/mL for their antibacterial activity against Gram+ve organisms such as Methicillin-Resistant Staphylococcus Aureus (MRSA), Gram-ve organisms such ...

In the present study evaluation of synergistic antimicrobial activity and antioxidant activity of blend of essential oil contains cardamom, coriander, fennel, caraway and ajowan were carried out. The essential oil was extracted from dried seed of cardamom, Coriander, Fennel, caraway and Ajowan were blend in sunflower oil used as base. The antibacterial activity and minimum inhibitory concentrat...

Objective: The aim of the present study was to develop a reversed phase high-performance liquid chromatography (RP-HPLC) method for simultaneous estimation of betulin, lupeol and stigmasterol in Asteracantha longifolia extract. Methods: The chromatographic separation was achieved using Luna C18 column (5 μm, 250 x 4.6 mm) under isocratic elution of acetonitrile and 0.1% acetic acid in water (94...

Background: Dinoprostone (prostaglandin E2), is presently used as the approved standard protocol for cervical ripening and labour induction. In search for a cheaper alternative, misoprostol (prostaglandin E1) has been found to be a good substitute. The ideal dose, route and frequency of administration of misoprostol are, however, still under investigation. Although, vaginal application of misop...

Results We found that at low doses Huang Qin induced cytotoxicity (1 μg/ml), but at high doses, 50-300 μg/ml, the same herb induced cell proliferation. Chuan Bei Mu exhibited a similar biphasic response with cytoxicity at 1-200 μg/ml but proliferation at 400 μg/ml. Data on Lian Qiao was scattered but the herb induced cytotoxicity at low doses from 1-10 μg/ml and less significantly at high doses...

Objective: To compare efficacy, safety and tolerance of combination Mifepristone Misoprostol versus alone in induction labour late intrauterine fetal death (>24 weeks).
 Methods: This prospectively study included 160 women with (IUFD) after 24 weeks gestation divided the randomly into two groups each containing 80 women. In Group-A : 200 mg single dose was given hrs Tab (intravaginally)...

BACKGROUND Expanding access to medication abortion through pharmacies is a promising avenue to reach women with safe and convenient care, yet no pharmacy provision interventions have been evaluated. This observational non-inferiority study investigated the effectiveness and safety of mifepristone-misoprostol medication abortion provided at pharmacies, compared to government-certified public hea...

BACKGROUND Central sensitization is a potential severe consequence of invasive surgical procedures. It results in postoperative and potentially chronic pain enhancement. It results in postoperative pain enhancement; clinically manifested as hyperalgesia and allodynia. N-methyl-D-aspartate (NMDA) receptor plays a crucial role in the mechanism of central sensitisation. Ketamine is most commonly u...

Labor induction despite an unriped cervix is one of the most common indications of the use of prostoglandines. This clinical trial was performed to compare the effectiveness of oxytocin with misoprostol for induction of labor in Bahonar Hospital, Kerman/lran from 1999 to 2000. Sixty pregnant women with indication for labor induction were randomly assigned to receive misoprostol or oxytocin. Mis...

Embryonic mesenchyme limb (LB) and midbrain (CNS) cells cultured at high density were exposed to different concentrations of the fungicide malachite green (MG) and its major metabolite leucomalachite green (LMG). The concentration response curves were analysed, and two endpoints were calculated: the concentrations (μg/mL) that produced 50% inhibition of viability/proliferation (IC50-P) and diff...