The reaction of 4-methyl-2-phenyl-1,2-dihydro-6-oxo-5-pyridine- carbonitrile (1) with arylidene malononitrile afforded isoquinoline derivatives 2a,b. 6-Chloro-4-methyl-2-phenyl-5-pyridinecarbonitile (3) obtained by chlorination of compound 1 with phosphoryl chloride was converted into 6-amino-4-methyl-2-phenyl-5-pyridinecarbonitrile (4) and 6-hydrazido-4-methyl-2-phenyl-5-pyridinecarbonitrile (...

5H-Chromeno[2,3-b]pyridines are important compounds with industrial, biological, and medicinal properties. In this short note, the multicomponent reaction of salicylaldehyde, malononitrile dimer, 2-phenyl-5-(trifluoromethyl)-2,4-dihydro-3H-pyrazol-3-one in dimethyl sulfoxide at ambient temperature was investigated to give 2,4-diamino-5-(5-hydroxy-1-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-5H...

Treatment of 4-heptafluoroisopropyl-2-methoxy-3,5,6-trifluropyridine (4 ) with aqueous ammonia in THF gave 2-amino-3,5-difluoro-4-heptafluoroisopropyl- 6-methoxy pyridine (5) in 7 1% yield. Chlorination of this amine with 'ButOCl at -16°C gave an unstable product, namely 2-dichloroarnino-3,5- difluoro-4-heptafluoroisopropyl-6-methoxy pyridine (6). Iodine-catalysed rearrangement of this dic...

The Front Cover shows 5-bromo-2-(tetrahydro-2H-pyran-4-yl)pyridine – one of many sp3-enriched pyridine derivatives prepared on a multigram scale by group Ukrainian chemists. background photo Anatolii Varenyk depicts the Kilometre Zero Ukraine Sign (also known as “The Winged Globe”) control point located Independence Square (Maidan Nezalezhnosti) in Kyїv. More information can be found Research A...

In the title compound, C(10)H(6)N(4)O(4), the pyridine rings are oriented at a dihedral angle of 67.8 (1)°. The O-atom pairs are trans, each displaced by a similar distance [average = 0.2331 (2) Å] out of the attached pyridine ring plane. In the crystal, inter-molecular C-H⋯O and C-H⋯N inter-actions link the mol-ecules into a three-dimensional network.