نتایج جستجو برای: 5 dihidro 1h imidazol

تعداد نتایج: 1236354  

2009
Pierre Koch Dieter Schollmeyer Stefan Laufer

In the title compound, C(14)H(10)FN(3), the imidazole ring makes dihedral angles of 28.2 (1) and 36.60 (9)° with the pyridine ring and the 4-fluoro-phenyl ring, respectively. The pyridine ring forms a dihedral angle of 44.68 (9)° with the 4-fluoro-phenyl ring. Inter-molecular N-H⋯N hydrogen bonds are observed in the crystal structure.

Journal: :Molecules 2017
Liang Zhang Fang Liu

Rapid and efficient analysis of fluoride ion is crucial to providing key information for fluoride ion hazard assessment and pollution management. In this study, we synthesized one symmetrical structure called 1,4-bis(4,5-diphenyl-1H-imidazol-2-yl)benzene (1a) and two asymmetrical structures, namely 2-(4-(4,5-diphenyl-1H-imidazol-2-yl)phenyl)-1H-phenanthro(9,10-d)imidazole (1b) and 2-(4-(4,5-dip...

2008
Lei Teng Yong Zhang Shi-lei Zhang Yuan Qu Xian-you Xia

In the title mol-ecule, C(15)H(15)N(3)O(2)S, the dihedral angle between the naphthalene ring system and the imidazole ring is 86.1 (2)°. In the crystal structure, weak inter-molecular C-H⋯O and C-H⋯N hydrogen bonds, as well as weak C-H⋯π inter-actions, connect mol-ecules, forming a two-dimensional network.

Journal: :physical chemistry and electrochemistry 0

stable crystalline phosphorus ylides are obtained in excellent yields from the 1:1:1 addition reactionbetween hydantoins or thiohydantoins and dialkyl acetylenedicarboxylates in the presence oftriphenylphosphine. these phosphoranes undergo smooth intramolecular wittig reaction followedby an electrocyclic ring opening to produce dialkyl (e)-2-(2,5-dihydro-5,5-diaryl-2-thioxo-1h-imidazol-4-yl)fum...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2013
Yohannes Teffera Loren M Berry Rachael L Brake Richard T Lewis Douglas C Saffran Earl Moore Jingzhou Liu Zhiyang Zhao

Compound 1 [(E)-4-fluoro-N-(6-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-1-((1S,4S)-4-(isopropylcarbamoyl)cyclohexyl)-1H-benzo[d]imidazol-2(3H)-ylidene)benzamide], a new, potent, selective anaplastic lymphoma kinase (ALK) inhibitor with potential application for the treatment of cancer, was selected as candidate to advance into efficacy studies in mice. However, the compound underwent mou...

Journal: :Molecules 2017
Fabian Heider Urs Haun Eva Döring Mark Kudolo Catharina Sessler Wolfgang Albrecht Stefan Laufer Pierre Koch

In vitro and in vivo metabolism studies revealed that 2-alkylsulfanylimidazole ML3403 (4-(5-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-4-yl)-N-(1-phenylethyl)pyridin-2-amine) undergoes rapid oxidation to the sulfoxide. Replacing the sulfur atom present in the two potent p38α mitogen-activated protein (MAP) kinase inhibitors ML3403 and LN950 (2-((5-(4-fluorophenyl)-4-(2-((3-methylbutan-2-yl)ami...

Journal: :Bitlis Eren University journal of science and technology 2022

The aim of the study was to synthesize 4- (p-tollyl) -5- (thiophene-2-yl) -2,4-dihydro-3H-1,2,4-triazole-3-thione and detect its experimental quantum chemical properties. 4-(p-tollil)-5-(tiyofen-2-il)-2,4-dihidro-3H-1,2,4-triazol-3-tiyon synthesized using by nucleophilic sübstitüsyon reaction. title compound has been characterized both experimentally theoretically calculations spectral techniqu...

Journal: :Dalton transactions 2011
Pankaj Kumar Apurba Kalita Biplab Mondal

Two copper complexes, 1 and 2, with tridentate N-donor ligands, L(1) and L(2) [L(1)= (1-methyl-1H-imidazol-2-ylmethyl)-(2-pyridin-2-yl-ethyl)amine, L(2) = (2-pyridin-2-yl-ethyl)-pyridin-2 yl-methylamine] respectively, have been synthesized and characterized. On exposure to nitric oxide, the copper(II) centers in complexes 1 and 2 were found to undergo reduction in various solvents. In acetonitr...

Journal: :Cancer research 1980
N Yoshida T Kiyohara M Fukui T Atsumi S Ogino M Inaba S Tsukagoshi Y Sakurai

In synthetic studies on the chemical modification of the nucleoside antibiotic bredinin, two new derivatives, 5-carbamoyl-1H-imidazol-4-yl 1-adamantanecarboxylate and 5-carbamoyl-1H-imidazol-4-yl piperonylate, were found to possess a potent antitumor activity in several experimental tumor systems, even though bredinin itself shows only in vitro cytotoxicity and thus lacks therapeutic effectiven...

Journal: :iranian journal of chemistry and chemical engineering (ijcce) 1995
majid m. heravi mehdi bakavoli zohreh sadjadi hashemi

6-methyl-2-phenyl-7h-oxazolo [3,2-b] [1,2,4] triazine (1) undersent ting transformation on treatment with ammonia and primary amines to afford the corresponding imidazol [1,2-b][1,2,4] triazine (2). treatment of (1) with hydrazine hydrate gave the corresponding 3-aryl-4h-1,2,4- triazino [4,3-b][1,2,4] triazin-8 (1h)-one (3).

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