نتایج جستجو برای: 5 dihidro 1h imidazol
تعداد نتایج: 1236354 فیلتر نتایج به سال:
In the title compound, C(14)H(10)FN(3), the imidazole ring makes dihedral angles of 28.2 (1) and 36.60 (9)° with the pyridine ring and the 4-fluoro-phenyl ring, respectively. The pyridine ring forms a dihedral angle of 44.68 (9)° with the 4-fluoro-phenyl ring. Inter-molecular N-H⋯N hydrogen bonds are observed in the crystal structure.
Rapid and efficient analysis of fluoride ion is crucial to providing key information for fluoride ion hazard assessment and pollution management. In this study, we synthesized one symmetrical structure called 1,4-bis(4,5-diphenyl-1H-imidazol-2-yl)benzene (1a) and two asymmetrical structures, namely 2-(4-(4,5-diphenyl-1H-imidazol-2-yl)phenyl)-1H-phenanthro(9,10-d)imidazole (1b) and 2-(4-(4,5-dip...
In the title mol-ecule, C(15)H(15)N(3)O(2)S, the dihedral angle between the naphthalene ring system and the imidazole ring is 86.1 (2)°. In the crystal structure, weak inter-molecular C-H⋯O and C-H⋯N hydrogen bonds, as well as weak C-H⋯π inter-actions, connect mol-ecules, forming a two-dimensional network.
stable crystalline phosphorus ylides are obtained in excellent yields from the 1:1:1 addition reactionbetween hydantoins or thiohydantoins and dialkyl acetylenedicarboxylates in the presence oftriphenylphosphine. these phosphoranes undergo smooth intramolecular wittig reaction followedby an electrocyclic ring opening to produce dialkyl (e)-2-(2,5-dihydro-5,5-diaryl-2-thioxo-1h-imidazol-4-yl)fum...
Compound 1 [(E)-4-fluoro-N-(6-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-1-((1S,4S)-4-(isopropylcarbamoyl)cyclohexyl)-1H-benzo[d]imidazol-2(3H)-ylidene)benzamide], a new, potent, selective anaplastic lymphoma kinase (ALK) inhibitor with potential application for the treatment of cancer, was selected as candidate to advance into efficacy studies in mice. However, the compound underwent mou...
In vitro and in vivo metabolism studies revealed that 2-alkylsulfanylimidazole ML3403 (4-(5-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-4-yl)-N-(1-phenylethyl)pyridin-2-amine) undergoes rapid oxidation to the sulfoxide. Replacing the sulfur atom present in the two potent p38α mitogen-activated protein (MAP) kinase inhibitors ML3403 and LN950 (2-((5-(4-fluorophenyl)-4-(2-((3-methylbutan-2-yl)ami...
The aim of the study was to synthesize 4- (p-tollyl) -5- (thiophene-2-yl) -2,4-dihydro-3H-1,2,4-triazole-3-thione and detect its experimental quantum chemical properties. 4-(p-tollil)-5-(tiyofen-2-il)-2,4-dihidro-3H-1,2,4-triazol-3-tiyon synthesized using by nucleophilic sübstitüsyon reaction. title compound has been characterized both experimentally theoretically calculations spectral techniqu...
Two copper complexes, 1 and 2, with tridentate N-donor ligands, L(1) and L(2) [L(1)= (1-methyl-1H-imidazol-2-ylmethyl)-(2-pyridin-2-yl-ethyl)amine, L(2) = (2-pyridin-2-yl-ethyl)-pyridin-2 yl-methylamine] respectively, have been synthesized and characterized. On exposure to nitric oxide, the copper(II) centers in complexes 1 and 2 were found to undergo reduction in various solvents. In acetonitr...
In synthetic studies on the chemical modification of the nucleoside antibiotic bredinin, two new derivatives, 5-carbamoyl-1H-imidazol-4-yl 1-adamantanecarboxylate and 5-carbamoyl-1H-imidazol-4-yl piperonylate, were found to possess a potent antitumor activity in several experimental tumor systems, even though bredinin itself shows only in vitro cytotoxicity and thus lacks therapeutic effectiven...
6-methyl-2-phenyl-7h-oxazolo [3,2-b] [1,2,4] triazine (1) undersent ting transformation on treatment with ammonia and primary amines to afford the corresponding imidazol [1,2-b][1,2,4] triazine (2). treatment of (1) with hydrazine hydrate gave the corresponding 3-aryl-4h-1,2,4- triazino [4,3-b][1,2,4] triazin-8 (1h)-one (3).
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