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Abstract Introduction Various agents have been tested to treat female sexual dysfunction (FSD), particularly Hypoactive Sexual Desire Disorder and Female Arousal Disorder, but only two, flibanserin bremelanotide, met any regulatory standards (US only), none is popular with patients or prescribers. Several more agents, e.g., sildenafil, testosterone, alprostadil, buspirone, bupropion trazodone, ...
BACKGROUND Malignant gliomas are the most common primary brain tumors in adults and challenging cancers for diagnosis and treatment. They remain a disease for which non-invasive, diagnostic and/or prognostic novel biomarkers are highly desirable. Altered microRNA (miRNA) profiles have been observed in tumor tissues and biological fluids. To date only a small set of circulating/serum miRNA is fo...
Aim: To compare the antimicrobial efficacy of five Medicinal plant extracts against two strains of Streptococcus mutans causing dental caries using Agar well diffusion method. Materials and methods: Five plant extracts were prepared by soxhlet extraction method using organic solvent. These extracts were tested against Streptococcus mutans MTCC 497& MTCC 890 causing dental caries by Agar well di...
MicroRNA analysis suggests an additional level of feedback regulation in the NF-κB signaling cascade
It is increasingly clear that the biological functions of a transcription factor cannot be fully understood solely on the basis of protein-coding genes that fall under its control. Many transcription factors regulate expression of miRNAs, which affect the cell by modulating translation and stability of mRNAs. The identities and the roles of NF-κB-regulated miRNAs have been attracting research i...
Vascular endothelial growth factor (VEGF) is a potent angiogenic cytokine that also increases vascular permeability. Nitric oxide (NO) released from endothelial cells, after activation of endothelial NO synthase (eNOS), contributes to proangiogenic and permeability effects of VEGF. Angiopoietin-1 (Ang-1), via Tie2 receptors, shares many of the proangiogenic properties of VEGF on endothelial cel...
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