Berin, M. Cecilia, Ping-Chang Yang, LeeAnn Ciok, Susan Waserman, and Mary H. Perdue. Role for IL-4 in macromolecular transport across human intestinal epithelium. Am. J. Physiol. 276 (Cell Physiol. 45): 1046–C1052, 1999.—Increased epithelial permeability is associated with intestinal inflammation, but there is little information on factors that regulate barrier function in the absence of or bef...

Segar, Jeffrey L., Oliva J. Smith, and Aaron T. Holley. Mechanoand chemoreceptor modulation of renal sympathetic nerve activity at birth in fetal sheep. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R1295– R1301, 1999.—Physiological responses at birth include increases in heart rate (HR), blood pressure, sympathetic nerve activity, and circulating vasoactive peptides. The fact...

setting, and an increasing number of emergency providers use point-of-care biliary sonography to rapidly evaluate symptomatic patients for the presence of cholelithiasis and its complications. Evaluation of elderly patients with suspected biliary sepsis is frequently complicated by altered mental status. In contrast to younger patients, sepsis from ascending cholangitis may be accompanied by at...

During pregnancy, maternal and fetal Ca demands are met through increased intestinal Ca absorption. Increased Ca absorption may be more dependent on oestrogen’s up-regulation of Ca transport genes than on vitamin D status. Numerous studies, however, have found that severe vitamin D deficiency with secondary hyperparathyroidism during pregnancy leads to abnormal Ca homoeostasis in the neonate. S...

Biesiadecki, Brandon J., Paul H. Brand, Lauren G. Koch, Patricia J. Metting, and Steven L. Britton. Phenotypic variation in sensorimotor performance among eleven inbred rat strains. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R1383–R1389, 1999.—As a first step toward identifying the genes that determine sensorimotor ability (motor coordination) we subjected 11 inbred strains...

Brito, M. N., N. A. Brito, S. R. C. Brito, M. A. F. Moura, N. H. Kawashita, I. C. Kettelhut, and R. H. Migliorini. Brown adipose tissue triacylglycerol synthesis in rats adapted to a high-protein, carbohydrate-free diet. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R1003–R1009, 1999.—Adaptation of rats to a high-protein, carbohydratefree (HP) diet induced a marked reduction o...

Ogut, Ozgur, Henk Granzier, and Jian-Ping Jin. Acidic and basic troponin T isoforms in mature fast-twitch skeletal muscle and effect on contractility. Am. J. Physiol. 276 (Cell Physiol. 45): C1162–C1170, 1999.—Developmentally regulated alternative RNA splicing generates distinct classes of acidic and basic troponin T (TnT) isoforms. In fast-twitch skeletal muscles, an acidic-to-basic TnT isofor...

Leffler, Charles W., Alberto Nasjletti, Changhua Yu, Robert A. Johnson, Alexander L. Fedinec, and Nicole Walker. Carbon monoxide and cerebral microvascular tone in newborn pigs. Am. J. Physiol. 276 (Heart Circ. Physiol. 45): H1641–H1646, 1999.—The present study addresses the hypothesis that CO produced from endogenous heme oxygenase (HO) can dilate newborn cerebral arterioles. HO-2 protein was ...

Jin, Lan, Lee Chao, and Julie Chao. Potassium supplement upregulates the expression of renal kallikrein and bradykinin B2 receptor in SHR. Am. J. Physiol. 276 (Renal Physiol. 45): F476–F484, 1999.—High potassium intake is known to attenuate hypertension, glomerular lesion, ischemic damage, and stroke-associated death. Our recent studies showed that expression of recombinant kallikrein by somati...

The vertebrate hypothalamus contains persistent radial glia that have been proposed to function as neural progenitors. In zebrafish, a high level of postembryonic hypothalamic neurogenesis has been observed, but the role of radial glia in generating these new neurons is unclear. We have used inducible Cre-mediated lineage labeling to show that a population of hypothalamic radial glia undergoes ...