Contributions of the Medical Corps of the Army to Special Articles: the Public Health Laboratory: COLONEL EDGAR ERSKINE HUME........................... 293 The Effect of Tryptophane D ficiency on Reproduction: DR. ANTHONY A. ALBANESE, ROMAINE Thomas Jefferson, the Scientist: FREDERICK E. MCI. RANDALL and DR. L. EMMETT HOLT, JR. BRoasCHfero,.300tnts:FRDRIEE Influence of Fever upon the Action of ...

A novel catalytic synthesis of 3,3'-(arylmethylene)-bis-(4-hydroxy-2H-chromene-2-one) derivatives from a tandem condensation reaction of 4-hydroxycoumarin and aromatic aldehydes has been developed. The reaction occurs in water in the presence of Melamine trisulfonic acid as catalyst to give the corresponding products in good to high yields. This green approach has several advantages such as sho...

A series of 4-hydroxycoumarin derivatives were designed and synthesized as new acetylcholinesterase (AChE) inhibitors which could be considered for Alzheimer's disease therapeutics. Among the 19 coumarin-derived compounds tested toward Electrophorus electricus acetylcholinesterase (eelAChE) and horse serum butyrylcholinesterase (eqBChE), N-(1-benzylpiperidin-4-yl)acetamide derivative 4m display...

The status of hepatic function can be altered by diverse influences. Multiple functional processes are measurably affected by several extrinsic toxic agents (typhoid toxin, chloroform, yellow phosphorus) as well as by a large number of pathological disorders. After exposure to toxins, in obstructive jaundice, in cirrhotic processes, in intrahepatic tumors and the like, either anatomical disrupt...

The rational design of 4-hydroxycoumarins with tailor-made antioxidant activities is required nowadays due to the wide variety of pharmacologically significant, structurally interesting of coumarins and researcher orientation toward green chemistry and natural products. A simple and unique coumarins have been achieved by reaction of 4-hydroxycoumarin with aromatic aldehyde accompanied with the ...

Solanum nigrum L. has been traditionally used as traditional Chinese medicine and food all over the world. Phytochemical investigations of immature fruits S. have carried out five coumarins (1-5) phenolic compounds (6-11) were obtained. Their structures elucidated on basis spectroscopic chemical methods, including IR, MS, 1H 13C-NMR. They identifies 6,7-dimethoxycoumarin (1), 6-methoxy-7-hydrox...

We report in this work successful isolation and cryopreservation of enterocytes from human small intestine. The enterocytes were isolated by enzyme digestion of the intestinal lumen, followed by partial purification via differential centrifugation. The enterocytes were cryopreserved directly after isolation without culturing to maximize retention of in vivo drug-metabolizing enzyme activities. ...

In this work, we attempted to synthesize thallium (III) oxide nano structures by direct thermal decomposition using thallium I phenylsuccinic acid coordination polymer [Tl(PsucH)]n as a precursor. Also, Tl2O3 nanoparticles have been characterized by scanning electron microscopy (SEM), X-Ray powder diffraction (XRD) and IR spectroscopy and then we report a simple and efficient method for the syn...