Phosphine-catalyzed [4 + 2] annulation and vinylogous Michael addition reactions between 1,4-dien-3-ones and 1,1-dicyanoalkenes are presented. Under the catalysis of PBu(3) (20 mol %), 1,4-dien-3-ones like styryl ketones with 2-aryl 1,1-dicyanoalkenes as doubly activated alkenes readily undergo a formal [4 + 2] cycloaddition reaction, affording polysubstituted cyclohexanones in satisfactory yie...

The possibility that the serum concentrations of various cholesterol precursors may reflect the activity of the hepatic HMG-CoA reductase was investigated in humans under different conditions. The serum levels of squalene, free and esterified lanosterol, (4 alpha, 4 beta, 14 alpha-trimethyl-5 alpha-cholest-8, 24-dien-3 beta-ol), two dimethylsterols (4 alpha, 4 beta-dimethyl-5 beta-cholest-8-en-...

Phytochemical examination of corncob extracts led to the isolation of a new lignan identified as 7,7'-dihydroxy-3'-O-demethyl-4-methoxymatairesinol, together with seven known compounds, identified as β-sitosterol, β-sitosteryl-β-D-glucoside, 6β-hydroxy-campest-4-en-3-one, 5α,8α-epidioxyergosta-6,22-dien-3β-ol, tricin, kaempferol and p-coumaric acid. The isolated compounds were identified by one...

The title compound, [Co(C(20)H(23)N(3)O(2))(C(5)H(11)N)](C(24)H(20)B) or [Co{(Me-sal)(2)dien}(pprdn)]BPh(4), where (Me-sal)(2)dien is 2,2'-[1,1'-(3-aza-pentane-1,5-diyldinitrilo)diethyl-idyne]diphenolate and pprdn is piperidine, contains a penta-dentate (Me-sal)(2)dien ligand furnishing an N(3)O(2) set, such that two of the N and one of the O atoms of the salicyl-idene rings define three positi...

The title compound, C(15)H(16)ClNO(3)S, was obtained by the organocatalytic asymmetric Michael addition of thian-4-one to 1-chloro-4-[(1E,3E)-4-nitro-buta-1,3-dien-yl]benzene. The double bond has an E configuration and the thian-4-one six-membered ring adopts a chair conformation. The crystal structure is stabilized by weak inter-molecular C-H⋯O hydrogen bonds.

Vernonia amygdalina was reported to be used as a therapy for Diabetes Mellitus (DM). One of the mechanisms DM inhibit action α-amylase enzyme. This study aimed prove presence compounds that could α-amylase. leaves were macerated with methanol and partitioned into n-hexane, dichloromethane (DCM), ethyl acetate (EtOAc). Furthermore, they tested inhibitory activity analyzed using liquid chromatogr...