نتایج جستجو برای: 4 d pyrimidine
تعداد نتایج: 1764910 فیلتر نتایج به سال:
The title compound, C13H11N3S, crystallizes with two independent mol-ecules in the asymmetric unit. The two mol-ecules are geometrically very similar and differ mainly in a spatial orientation of the benzene and thieno[3,2-d]pyrimidine ring systems [dihedral angles = 69.49 (4) and 79.05 (3)°]. The nine-membered thieno[3,2-d]pyrimidine moieties have a planar conformation (r.m.s. deviations = 0.0...
The effect of a single injection of a therapeutic level of either 4-aminopyrazÃ3lo(3,4rf)pyrimidine or l-methyl-4-aminopyrazolo(3,4-¿)pyrimidine on the incorporation of glycine-C14, adenine-C14, or guanine-C14 into RNA and DNA adenine and guanine during the 12-hour period after drug administration has been studied in the Ehrlich ascites carcinoma, which is sensitive to both drugs, and in Sarco...
A series of piperazin-1-yl substituted unfused heterobiaryls was synthesized as ligands of the 5-HT₇ receptors. The goal of this project was to elucidate the structural features that affect the 5-HT₇ binding affinity of this class of compounds represented by the model ligand 4-(3-furyl)-2-(4-methylpiperazin-1-yl)pyrimidine (2). The SAR studies included systematical structural changes of the pyr...
we wish to report a mild and efficient one-pot three-component reaction of an aryl aldehyde, malononitrile and barbituric acid or 4-hydroxycoumarinfor the synthesis ofpyrano[2,3-d]pyrimidine and dihydropyrano[c]chromene derivatives in the presence of iron ore pellet as a natural and reusable catalyst under heterogeneous and green conditions. the present methodology offers several advantages suc...
The crystal structure of the title compound, C5H4N2O2, is built of acid mol-ecules located on a mirror plane. They form sheets stacked along the b-axis direction. The mol-ecules inter-act via O-H⋯N hydrogen bonds, forming [001] chains, and weak van der Waals inter-actions.
Fused pyrimidine cores are privileged kinase scaffolds, yet few examples of the 2-amino-pyrido[3,4-d]pyrimidine chemotype have been disclosed in the context of kinase inhibitor programs. Furthermore, no general synthetic route has been reported to access 2-amino-pyrido[3,4-d]pyrimidine derivatives. Here we report a versatile and efficient chemical approach to this class of molecules. Our strate...
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