in radiation cancer treatments, the most of the side effects could be minimized using a proper dosimeter. gel dosimeter is the only three‑dimensional dosimeter and magnetic resonance imaging (mri) is the gold standard method for gel dosimeter readout. because of hard accessibility and high cost of sample reading by mri systems, some other alternative methods were developed. the optical computed...

There is significant interest in delivering precisely targeted small-volume radiation treatments, in the pre-clinical setting, to study dose-volume relationships with tumor control and normal tissue damage. In this work we investigate the IGRT targeting accuracy of the XRad225Cx system from Precision x-Ray using high resolution 3D dosimetry techniques. Initial results revealed a significant tar...

BACKGROUND Red bone marrow (RBM) toxicity is dose-limiting in (pretargeted) radioimmunotherapy (RIT). Previous blood-based and two-dimensional (2D) image-based methods have failed to show a clear dose-response relationship. We developed a three-dimensional (3D) image-based RBM dosimetry approach using the Monte Carlo-based 3D radiobiological dosimetry (3D-RD) software and determined its additio...

This study presents the application of the Presage/optical-CT 3D dosimetry system for relative dosimetry in the Radiologic Physics Center (RPC) Head and Neck (H&N) IMRT phantom. Performance of the system was evaluated by comparison with the "gold-standard" RPC credentialing test. A modified Presage cylindrical insert was created that extended the capability of the RPC H&N phantom to 3D dosimetr...

introduction the use of cut-outs in electron applicators make changes on output, isodose, and percentage depth dose (pdd) curves. these changes and electron beam dose distribution in the form of three-dimensional (3d) can be measured by gel dosimeters. materials and methods dosimetry was performed with and without a square shield (6×6 cm2 field). the energies were 4, 9, and 16 mev and phantom w...

The use of polymer gels to record radiation dose distributions in three dimensions was first proposed in 1992 as a proof-of-principle [1]. The accuracy of these early polymer gel dosimeters and scanning methods was not sufficient for most clinical applications [2]. Since then, several efforts were made to increase the accuracy and precision of both the physical gel dosimeter and the scanning te...