OBJECTIVE Recently, many studies have shown that microRNAs (miRNA) exhibit altered expression in various cancers and may play an important role as prognostic biomarker of cancers. We performed a meta-analysis to evaluate the impact of miR-375 expression in solid tumors on patients' overall survival (OS). METHODS Studies were identified by searching PubMed, Embace, and Cochrane Library (last s...

Argonaute2 (Ago2) is an established component of the microRNA-induced silencing complex. Similar to miR-375 loss-of-function studies, inhibition of Ago2 in the pancreatic β-cell resulted in enhanced insulin release underlining the relationship between these two genes. Moreover, as the most abundant microRNA in pancreatic endocrine cells, miR-375 was also observed to be enriched in Ago2-associat...

Alexander M. Krot, Mikhail A. Shcherbakov and Polina P. Tkachova Institute of Engineering Cybernetics of the National Academy of Sciences of Belarus Surganov Str., 6, 220012, Minsk, Belarus e-mail: [email protected] Tel.: (375) 172 842086, Fax.: (375) 172 318403 State Technical University of Penza Krasnaya Str., 40, 440017, Penza, Russia Belarusian State University Skoriny av. 4, 2...

Pacific Palisades, CA (US) 90272-2440; 6,662,337 B1 * 12/2003 Brink ......................... 714/792 Samuel J. Dolinar, 8859 Riderwood Dr., 6,754,290 B1 * 6/2004 Halter ........................ 375/340 Sunland, CA (US) 91040-2624; Fabrizio 6,795,507 B1 * 9/2004 Xin et al . .................... 375/265 Pollara, 181 Starlight Crest Dr., La 7,089,477 BI 8/2006 Divsalar et al. Canada, CA (US) 9101...

An attempt is made to match observed properties of supernovae, such as spectra, lightcurves etc. with theoretical ideas and predictions. It is demonstrated that neither do observational data constrain the models in a unique way nor does theory allow for an unambiguous interpretation of the data. Possible improvements on the theoretical side are briefly discussed. Some Observational Facts In gen...

A low dose of formononetin accelerates the proliferation of nasopharyngeal carcinoma cells in vitro; however, the underlying mechanism remains unknown. Here, we investigated the molecular mechanism of formononetin in CNE2 cell proliferation. CNE2 cells were treated with 0 to 1 μM formononetin. To inhibit mitogen activated protein kinase / extracellular regulate kinase (MAPK/ERK) kinase (MEK) an...

Several lines of evidence indicate that microRNAs (miRNAs) modulate tolerance to the analgesic effects of morphine via regulation of pain-related genes, making dysregulation of miRNA levels a clinical target for controlling opioid tolerance. However, the precise mechanisms by which miRNAs regulate opioid tolerance are unclear. In the present study, we noted that the miR-375 level was downregula...

Cervical cancer results from persistent infection with high-risk human papillomavirus (hrHPV). Common genetic aberrations in cervical (pre)cancers encompass large genomic regions with numerous genes, hampering identification of driver genes. This study aimed to identify genes functionally involved in HPV-mediated transformation by analysis of focal aberrations (<3 Mb) in high-grade cervical int...